摘要
目的 :探讨辽宁地区汉族原发性高血压病人与血管紧张素转换酶 (ACE)基因多态性的关系。方法 :应用聚合酶链反应检测 6 9例原发性高血压 (EH )病人及 99例健康汉族人的 ACE基因多态性的分布情况。结果 :EH组的基因型分别为 :纯合插入型 (II) 2 1.7%、纯合缺失型 (DD) 34.8%、杂合型 (ID) 4 3.5 % ;正常对照组分别为 :39.4%、14.1%、46 .9%。前者 D等位基因频率 (0 .5 6 5 )明显高于对照组 (0 .374) ;女性 EH病人 D等位基因频率 (0 .6 2 5 )也明显高于对照组 (0 .32 1) ;同时 DD型高血压病人临床症状重 ,预后较差。结论 :ACE基因多态性可能与 EH及性别有关 ,DD型基因可能是
Objective: Our purpose was to investigate the association between essential hypertension (EH) among people of Han nationality in Liao Ning province and angiotensin I converting enzyme (ACE) gene polymorphism. Methods: The insertion/deletion (I/D) polymorphism of ACE gene was detected by polymerase chain reaction in 69 EH patients and 99 normotensive subjects. Results: Genetypes were homozygous inserting (II, 21.7%), homozygous deletion (DD, 34.8%), and heterozygous (ID, 43.5%), in EH patients. Their expression in normal control were 39.4%, 14.1%,and 46.9%. The frequency of the ACE D allele was higher in the EH group (0.565) than that in normal control group (0.374). The frequency of the ACE allele was higher in the female EH patients (0.625) than that in the healthy women (0.321). At the same time, clinical symptoms of the patients with the D allele were severe, and unfavourable prognosis of the patients was found. Conclusion: These findings suggest that a deletion polymorphism is associated with EH and sexuality in China.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2000年第5期372-373,共2页
Journal of China Medical University
关键词
原发性高血压
血管紧张素转换酶
基因多态性
essential hypertension
angiotensin I converting enzyme
gene polymorphism
