摘要
目的 探讨血清PSA密度 (PSAD)在前列腺活检中的意义。方法 对 173例血清PSA升高 ,有阳性直肠指诊或异常直肠B超发现者 ,进行了前列腺活检 ,对血清PSAD与前列腺活检的关系进行分析。 结果 173例活检的前列腺肿瘤阳性率为 5 0 3 % (87/ 173) ,其中前列腺癌 84例 ,肉瘤 2例 ,移行细胞癌 1例。当血清PSA为 4～ 2 0ng/ml,PSAD <0 .15时 ,其敏感性和特异性分别为10 0 .0 %和 0 0 % ;PSAD >0 45时 ,分别为 18 2 %和 10 0 .0 %。PSAD >0 1时 ,敏感性 ,特异性和阳性预检值分别为 90 9% ,2 8 9%和 38 5 % ;>0 15时分别为 78 8% ,5 0 0 %和 41 3%。 结论 血清PSA为 4～ 2 0ng/ml时 ,PSAD在前列腺活检中有意义 ,当PSAD <0 .45时 ,应高度怀疑前列腺癌 ,<0 .0
Objective To study the role of prostate specific antigen density (PSAD) in prostate biopsy. Methods In 173 patients with elevated serum PSA,positive digital rectal examination or abnormal transrectal ultrasonography,prostate biopsy was conducted and the role of PSAD in prostate biopsy was studied. Results The positive rate of prostate tumors was 50.3%.(87/173),84 cases of prostate carcinoma,2 sarcoma and 1 case of transitional cell carcinoma.When serum PSA was 4～20ng/ml and PSAD<0.15,the sensitivity and specificity of PSAD were 100% and 0% respectively.If >0.45,these were 18.2% and 100.0%.When PSAD was>0.1,the sensitivity,specificity and the predict positive tumor rate were 90.9%,28.9% and 38.5%.When>0.15,these were 78.8%,50.0% and 41.3% respectively. Conclusions High suspicion of prostatic cancer should be noted if PSAD is >0.45.If PSAD is <0.05 and serum PSA ranges from 4.0ng/ml to 20.0ng/ml,prostate biopsy is not needed.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2000年第10期624-626,共3页
Chinese Journal of Urology
