摘要
为了评价前列腺特异抗原密度(PSAD)在前列腺癌(CaP)诊断中的作用以及在对前列腺癌和前列腺增生(BpH)的鉴别诊断中的价值。我们于1996年3月-1997年4月对经病理学诊断的26例CaP和56例BpH患者的PSA和PSAD进行了检测研究。结果显示:PSA对CaP诊断的敏感性高,而特异性低;以0.15为界值,PSAD可提高诊断的特异性,而敏感性无明显降低;对于PSA在4-10ng/ml时,CaP组的PSAD值显著高于BpH值(P<0.05),而且在此区间,PSAD对CaP的检出率大于PSA。故认为当PSA轻度升高时,若PSAD>0.15,考虑行前列腺穿刺活捡,可以提高CaP的早期诊断率。
From 1996 to 1997,serum PSA and PSAD of 26 cases of prostatic cancer and 56 cases ofBpH verified by pathological examination were detectecd .The results showed that PSA had a sensitivity of84. 6% and a specificity of 44. 6% with the cutoff level of 4ng/ml. If 0. 15 as the catoff level of PSAD,the specificity obvionsly reach a higher level (69.6%) but without significant change of its sensitivity(61.5%). When PSA was between 4-10ng/ml, the PSAD level of prostatic cancer group was obviouslyhigher than that of BpH group(p<0. 05), whatmore the positive rate of prostatic cancer detected by PSADwas higher than by PSA .So we think that when PSA rise slightly with PSAD higher than 0. 15, prostatepuncture biopsy should be undertaken to promote the detective rate of prostatic cancer.
