摘要
目的 分别观察多种病毒感染后血清心肌肌钙蛋白I(cTnI)变化 ,结合心电图 (ECG)及临床特征 ,阐述其对病毒性心肌炎 (VMC)心肌损伤的诊断价值。方法与结果 VMC患者 180例ELISA双抗夹心法定量测定血清cTnI ,升高 97例 (5 4% ) ,其中重症 19例、有病毒感染史与ECG改变 2 7例血清cTnI均增高。 19例丙型病毒性肝炎患者 ,8例血清cTnI增高。 5 0例带状疱疹病毒感染者 2 0例血清cTnI增高 ,且与临床严重度有关 ,其中 17例ECG呈多样性表现。 6 5例VMC且cTnI持续增高者在病程 1、3、6、9、12个月时转阴率分别为 47 7%、5 2 3%、90 8%、92 3 %、98 5 %。
Objective To evaluated the diagnostic values of serum cardiac troponin I(cTnI)in the patients with viral myocarditis(VMC) according to the data from individual analysis of the electrocardiograms(ECG)and clinical symptoms,serum cTnI levels.Method and Result Seurm cTnI level was assayed by ELISA method with two monoclonal antibodies against cTnI.Seurm cTnI level was elevated in 97 of 180 patients that was 54% myocarditis following the diagnostic criteria issued 1995.The rate of serum cTnI increased in all 19 serious patients (Ⅱ or Ⅲ A V Block,heart failure)was 100%.Serum cTnI levels were elevated in 20 of 50 patients with varicella zoster myocarditis,and in which only 17 of 20 patients had abnormal unspecific change of ECG.The rate of cTnI turned to be negative at 1,3,6,9 and 12 months in 65 cases of VMC were 47 7%,52 3%,90 8%,92 3% and 98 5% respectively.Conclusion Serum cTnI is a highly sensitive and specific marker for determining cardiac injury and detecting myocyte injury in patients infected with several viruses.
出处
《江苏医药》
CAS
CSCD
2000年第10期753-754,共2页
Jiangsu Medical Journal
基金
国家"九五"攻关基金!(96 90 60213)
江苏省科委社会发展基金!(BS9702 8与BS980 39)
江苏省卫生厅项目!(H970 1)
