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急性心肌梗死患者血浆脑纳肽、D-二聚体的检测与分析 被引量:4

Study of Plasma Brain Natriuretic Peptide and D-dimerin Patiens with Acute Mycardial Infarction
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摘要 目的通过检测急性心肌梗死(AMI)患者血浆中脑钠肽又称B型利钠肽(BNP)和D-二聚体(DD)的含量,探讨其二者与AMI的相关性,分析它们在AMI发生发展过程中的作用,为临床诊治AMI提供一定的参考依据。方法分别采用酶联免疫法和全定量金标法测定45例AMI患者和47例健康对照者血浆中的BNP和DD含量,将患者组与对照组进行比较。结果 AMI患者组血浆中BNP含量(458.6±399.8)ng/L、DD含量(0.64±0.17)mg/L,对照组血浆中的BNP含量(29.8±20.3)ng/L,DD含量(0.27±0.06)mg/L,两者相比,AMI患者组血浆中BNP和DD含量都明显高于健康对照组,差异均有统计学意义。患者组BNP含量、DD含量与正常组比较,P均<0.01。结论 BNP和DD均参与了AMI的病理过程,检测急性心脑血管患者血浆中的BNP和DD对AMI的诊断和治疗有一定的临床意义。 Objective Detect the concentration of brain natriuretic peptide(BNP) and D-dimer(DD) in blood plasma in patiens with acute myocardial infarction(AMI),and investigate the value.Methods Brain natriuretic peptide(BNP),D-dimer(DD) in blood plasma of 45 patiens with AMI and 47 normal controls were measured by ELISA and the gold standard method for quantitative.Results The levels of BNP and DD were(458.6 ±399.8) ng/L and(0.64±0.17) mg/L in blood plasma of the 45 patients with AMI.The levels of BNP and DD were(29.8±20.3) ng/L and(0.27±0.06) mg/L.In another health group,the levels of BNP and DD were(29.8±20.3) ng/L and(0.27±0.06) mg/L.Compared with AMI and control group,the levels of BNP and DD were significantly higher in patiens with AMI in the control(P0.01).Conclusion BNP and DD participate in the AMI on that happen development.
作者 刘芳 毋小玉
出处 《中华全科医学》 2013年第3期465-466,共2页 Chinese Journal of General Practice
关键词 急性心肌梗死 脑钠肽 D-二聚体 酶联免疫法 Acute myocardial infarction Brain natriuretic peptide D-dimer ELISA
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