摘要
肺癌发病率及病死率居恶性肿瘤首位,严重威胁着人类的健康,但目前仍存在早期诊断率低、治疗效果差及预后不良等问题,开发新的肺癌标志物及治疗位点成为迫切的需要。近年的研究显示,sox4基因在各类型肺癌中均呈异常的高表达,与肿瘤的生物学行为密切相关,因此深入研究该基因与肺癌的关系对肺癌的早期诊断、预后判断和治疗具有重要意义。
The incidence and mortality of lung cancer rank first among the malignant tumors,which is a serious disease threatening human health and life.But there are still existing problems like low rate of early diagnosis,poor response to treatment and poor prognosis.So,it is urgent to explore new diagnosis marker and therapeutic targets.Recent researches have revealed that sox4 gene was overexpressed in all kinds of lung cancers,which was closely related to the biological behavior of tumor,therefore in-depth study of sox4 gene has great significance in early diagnosis,prognosis judgment and treatment of lung cancer.
出处
《医学综述》
2013年第5期823-826,共4页
Medical Recapitulate
基金
国家自然科学基金(81060177)
云南省应用基础研究面上项目(2010CD081)
云南省应用基础研究基金(2009CD181)
