摘要
目的观察达英-35、盐酸二甲双胍联合克罗米芬治疗多囊卵巢综合征不孕的疗效。方法选择2010年1月至2012年3月不孕科接收的多囊卵巢综合征患者60例,随机均分为A组和B组。两组均使用达英-35联合克罗米芬治疗,达英-35连服21 d为1个疗程,在3个疗程内复查雄激素恢复正常后,停用达英-35,下一月经周期第5天服用克罗米芬片,连服5 d,连续用3个疗程后仍无排卵为无效,最多5个疗程。B组在此基础上从一开始就加用盐酸二甲双胍片至治疗结束。结果 A组的排卵率与妊娠率明显低于B组,两组患者治疗前后的激素水平改变存在明显差异(P<0.05)。结论达英-35、盐酸二甲双胍、克罗米芬三者联合应用,可降低多囊卵巢综合征患者高雄激素水平与高胰岛素血症,促进促卵泡生成素的分泌,保证了排卵率与妊娠率,提高了治疗效果。
Objective To observe the polycystic ovary syndrome infertility efficacy treatment with the Diane-35, metformin hydrochloride Combined clomiphenc citrate. Methods Sixty cases of polycystic ovary syndrome patients in the department of infertility of our hospital from January 2010 to March 2012 were selected and randomly divided into group A and group B. The group A were given Diane-35 and clomiphene,Diane-35 even serving 21 d for a course,review of androgen （T） return to normal after 3 courses of treatment,disabled Di- ane-35,5 d of the next menstrual cycle taking Clomiphene Citrate Tablets,and even served 5 d,continuous use after 3 courses of no ovula- tion to be invalid, the use of up to 5 courses. The Group B were given Diane-35, metformin hydrochloride combined treatment of clomiphene citrate,Diane-35 and metformin hydrochloride tablets treated at the same time,3 cycles of androgen normal control,disable Diane-35 and metformin to continue with the former taking the next a menstrual cycle for 5 d, taking clomiphene citrate,observed 2 to 3 cycles still no ovulation,elomiphene citrate is invalid,the use of up to five courses. Results The ovulation rate and pregnancy rate of group A was significantly lower than group B,two groups of patients hormone levels change was significantly different （P 〈 0.05）,with statistical significance. Conclusion Diane-35,metformin hydrochloride,clomiphene three joint use by inhibition of androgen secretion,ovulation,the discharge of insulin resistance,reduce androgen levels and hyperinsulinemia in women with polycystic ovary syndrome,promote and promote follicle hormone secretion,to ensure that the ovulation rate and pregnancy rate,improve the treatment of pulycystic ovaly syndrome.
出处
《中国药业》
CAS
2013年第5期16-17,共2页
China Pharmaceuticals
关键词
达英-35
盐酸二甲双胍
克罗米芬
多囊卵巢综合征
不孕
Diane - 35
metformin hydroehloride clomiphene citrate
polycystic ovary syndrome
infertility
