摘要
目的:探讨子宫内膜不典型增生(AEH)的临床特点和影响诊断的相关因素。方法:回顾性分析广西医科大学第一附属医院77例术前诊断为AEH患者的临床病理资料,根据术后病理诊断分为子宫内膜癌组(A组,50例)和AEH组(B组,27例)进行比较分析。结果:A组全部为子宫内膜样腺癌,占64.9%,B组占35.1%;两组年龄比较,t=2.708,P=0.008<0.05,差异有统计学意义;术后病理诊断与术前诊刮AEH的分度有关,轻、中、重度AEH合并子宫内膜癌率分别为28.6%、42.1%、78.4%;两组肿瘤标记物CA125比较,P=0.140>0.05,差异无统计学意义。结论:①年龄是AEH合并子宫内膜癌的高危因素;②随着诊刮AEH分度增加,合并子宫内膜癌有增加趋势;合并子宫内膜癌多数分化较好、浸润少、期别以Ⅰ期为主。③血清CA125不是预测AEH合并子宫内膜癌的敏感指标。
Objective： To explore the clinical characteristics of atypical endometrial hyperplasia （AEH） and the related influen- cing factors. Methods： The clinicopathological data of seventy - seven patients diagnosed as AEH in the hospital preoperatively were ana- lyzed retrospectively, then they were divided into two groups according to postoperative pathological diagnosis： endometrial cancer group （group A, 50 cases） and AEH group （group B, 27 cases） , the results in the two groups were compared, l^esults： The cases in group ~＇~ were diagnosed as endometrioid adenocarcinoma, which accounted for 64. 9% , and the cases with endometrioid adenocarcinoma in group B accounted for 35.1%. There was statistically significant difference in age between the two groups （ t = 2. 708, P = 0. 008 ） . The postol）cra- tire pathological diagnosis was associated with preoperative degree of AEH after uterine curettage： the coexistence rates of endometrial carcinoma with AEH of slight, moderate, and high degrees were 28.6% , 42. 1% , and 78.4%, respectively. There was no statistically signifi- cant difference in the concentration of tumor marker （CA125） between the two groups （P 〉 0. 05） . Conclusion： Age is a high risk factor for coexistence with endometrial carcinoma. With the progression of AEH degree, the trend of coexistence with endometrial carcinoma en- hances. The coexistent with endometrial carcinoma is mostly staged in FIGO I with high differentiation and less infiltration. Sermn CA125 is not a sensitive index for indicating AEH coexisting with endometrial carcinoma.
出处
《中国妇幼保健》
CAS
北大核心
2013年第9期1424-1426,共3页
Maternal and Child Health Care of China
关键词
子宫内膜不典型增生
子宫内膜癌
诊断性刮宫
Atypical endometrial hyperplasia
Endometrial carcinoma
Diagnostic curettage
