摘要
目的:探讨测定唾液中胃蛋白酶原的浓度与胃食管反流病的相关性研究。方法:选取我院确诊的胃食管反流病患者27例(GERD组),慢性胃炎患者29例(慢性胃炎组),健康者20例(健康对照组),晨起空腹收集唾液3～5mL,以乳胶增强免疫比浊法检测唾液中胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)的浓度。结果:与健康对照组比较,GERD组PGⅠ浓度、PG总浓度均较高(PⅠ=0.00,P总=0.01);与慢性胃炎组比较,GERD组PGⅠ浓度较高(P=0.02)。GERD组患者的GerdQ表评分与PGⅠ浓度存在正相关关系,ROC分析显示,PGⅠ临界值取2.5μg/L时,对GERD的诊断敏感度为70.4%,特异度为71.4%。结论:唾液中的PGⅠ浓度是提示反流症状的一个敏感指标,唾液中PGⅠ浓度与胃食管反流病存在相关性。
Objective To investigate the correlation between the concentration of saliva pepsinogen and gastroesophageal reflux disease. Methods 27 cases with gastroesophageal reflux disease （GERD group）, 29 cases with chronic gastritis （gastritis group）, and 20 cases of healthy controls （control group） in our hospital were included. 3-5 mL of saliva of all cases was collected in the morning, then the concentrations of saliva pepsinogen I （PG I ） and saliva pepsinogen l] （PG ]] ） were detected by particle-enhanced turbidimetrie immunoassay. Results As compared to those in control group, the concentration of PG I and the total concentration of PG I and PG U in GERD group was higher （P = 0.00, P = 0.01 ）. The concentration of PG I in GERD group was higher than that in gastritis group （P = 0.02）. There was a positive correlation between GerdQ scores and the concentration of PG I in GERD group. Taking 2.5μg/L of saliva PG I as the cut-off value for GERD, the sensitivity and specificity were 70.4% and 71.4%, respectively. Conclusion The concentration of PG I in saliva was a sensitive index for indicating regurgitation, and the concentration of PG I in saliva was positively correlated with GERD.
出处
《实用医学杂志》
CAS
北大核心
2013年第6期913-915,共3页
The Journal of Practical Medicine
关键词
唾液
胃蛋白酶
胃食管反流病
Saliva
Pepsinogen
Gastroesophageal reflux disease
