摘要
从双氨基甲基手性双环胍出发，经三步反应合成了由稳定的共价键桥联双环胍、氮杂冠醚和萘环的氨基酸受体１。液－液竞争萃取和＾１Ｈ ＮＭＲ实验表明受体对氨基酸两性离子具有较好的侧链选择性和对映选择性，能够选择性地将Ｌ－芳香族氨基酸从水相转移到二氯甲烷有机相。
A novel artificial receptor 1 for aromatic amino acid zwitterions was prepared in three steps from the
chiral bis(aminomethyl) bicyclic guanidinium salt. The bicyclic guanidinium group is covalently connected with an azacrown ether and three naphthylmethyl group by means of chemically stable amide and imino bonds. The experiments of the competition extraction and 1H NMR indicated that the receptor selectively binds to L-aromatic amino acid zwitterions and can transfer it from water into dichloromethane.
出处
《化学学报》
SCIE
CAS
CSCD
北大核心
2000年第7期890-894,共5页
Acta Chimica Sinica
基金
国家自然科学基金(29872014)
南京大学现代分析中心测试基金资助项目
关键词
氨基酸
合成
分子识别
人工受体
萃取性质
receptor, amino acid, synthesis, extraction, molecular recognition
