摘要
目的观察复方丹参滴丸联合氯吡格雷片对不稳定型心绞痛患者的作用。方法将102例不稳定型心绞痛患者随机分为3组,在常规治疗的基础上,复方丹参滴丸组(33例)给予复方丹参滴丸每次270mg,每日2次,口服。氯吡格雷片组(35例)给予氯吡格雷片每次75mg,每日1次,口服。联合治疗组(34例)给予前两种治疗方案联合治疗。各组均治疗3周后观察患者的症状疗效及心电图疗效,测定血小板聚集率及血栓素B2(TXB2)。结果复方丹参滴丸组、氯吡格雷片组、联合治疗组症状疗效总有效率分别为90.9%、91.4%、94.1%,心电图疗效总有效率分别为81.8%、85.7%、88.2%,各组症状及心电图总有效率比较差异无统计学意义(P>0.05)。各组患者治疗后血小板聚集率及TXB2较治疗前均明显降低(P<0.01)。治疗后联合治疗组的血小板聚集率和TXB2降低程度明显优于其他两组(P<0.05)。结论复方丹参滴丸联合氯吡格雷片在抗血小板聚集方面明显优于单用复方丹参滴丸或氯吡格雷片。
Objective To observe the effect of Compound Danshen Dripping Pill （CDDP） combined with clopidogrel for un- stable angina （UA）. Methods Totally 102 UA patients were randomized into the CDDP group （33 cases）, clopidogrel group （35 cases） and CDDP＋clopidogrel group （34 cases）. The patients in the CDDP group were orally taken 270 mg CDDP twice daily on the basis of routine treatment. The patients in the clopidogrel group were orally taken 75 mg clopidogrel once daily. The CDDP＋clopidogrel group was given the combo therapy of the CDDP group and clopidogrel group. After the treatments were given to each of groups for 3 weeks, the improvement of clinical symptoms and electrocardiogram （ECG） ST segment changes were evaluated. The platelet aggregation function and thromboxane B2 （TXB2） levels were measured before and after treatment. Results There was no significant difference between groups in the total effective rate and ECG effective rate （P〈 0.05）. The platelet aggregation rates and TXBz levels were significantly decreased in all groups after treatment （P〈0.01）, es- pecially in the CDDP＋clopidogrel group （P〈0.05）. Conclusion The combo therapy of clopidogrel and CDDP is more effec- tive in inhibiting platelet aggregation than single treatment. It provides the basis for clinical integrative antitbrombotic therapy.
出处
《中医杂志》
CSCD
北大核心
2013年第6期500-502,共3页
Journal of Traditional Chinese Medicine
