摘要
目的探讨奥拉西坦对精神分裂症患者认知与社会功能的影响。方法采用对照研究,比较奥拉西坦合并奥氮平组和单用奥氮平组患者认知和社会功能变化。结果①治疗后合并用药组个人与社会功能量表(PSP)(t=2.163,P=0.027)和威斯康辛片卡分类测验(WCST)完成分类数(t=2.321,P=0.015)得分高于奥氮平组,错误应答数(t=-3.546,P=0.004)得分低于奥氮平组,均存在显著性差异(P<0.05,P<0.01);②相关分析显示:疗效与PSP(r=0.41)、分类完成数(r=0.32)呈正相关,与错误应答数(r=-0.27)呈负相关(P<0.05)。结论奥拉西坦可能与精神分裂症的认知功能、个人和社会功能的改善存在关联。
Objective To explore the effect of Oxiracetam on cognitive and social function in schizophrenia patients. Methods By using case-control study,to compare the difference of cognitive and social function between Oxiracetam combined Olanzapine （group I）and only Olanzapine（group II）treatment group. Results （~There were significantly higher level of PSP（t=2. 163,P= 0. 027） and number of trials （t = 2.321,P = 0. 015）,but lower level of total errors （t =-3. 546,P = 0. 004）of WCST in group I than in group II （P〈0.05）.② Correlation anaiysis showed that PANSS change had positive correlation with PSP （r： 0. 41）and number of trials（r=0.32） ,but had negative correlation with total errors（r=-0.27）of WCST（P〈0.05）. Conclusion Oxiracetam treat- r^ent may be associated with cognitive and social function in schizophrenia patients.
出处
《中国健康心理学杂志》
2013年第3期339-341,共3页
China Journal of Health Psychology
