摘要
目的分析感染性心内膜炎患者的病原菌的构成及其耐药性,以指导临床合理用药。方法选取临床140例感染性心内膜炎患者经血液培养分离得到病原菌,并利用药敏试验对病原菌的耐药性进行分析。结果病原菌中主要革兰阳性菌为酿脓链球菌72株占49.7%、金黄色葡萄球菌14株占9.7%、表皮葡萄球菌11株占7.6%、肠球菌属7株占4.8%、溶血性葡萄球菌6株占4.1%;主要革兰阴性菌为嗜麦芽寡养单胞菌16株占11.0%、大肠埃希菌11株占7.6%;革兰阳性菌对克拉霉素和利奈唑胺的耐药率较低,革兰阴性菌对亚胺培南、阿米卡星和美罗培南的耐药性较低。结论感染性心内膜炎患者临床应依据病原菌的类型合理选择抗菌药物进行治疗,以减低耐药菌的产生。
OBJECTIVE To investigate the distribution and drug resistance of the pathogens causing infectious endocarditis so as to guide the reasonable clinical use of antibiotics. METHODS A total of 140 cases of patients with infectious endocarditis were selected, and the pathogens were isolated from the blood, and the drug resistance was analyzed through the drug susceptibility testing. RESULTS Of the main gram-positive bacteria, there were 72 （49.7%） strains of Streptococcus viridans, 14 （9. 7%） strains of Staphylococcus aureus, 7（4. 8%） strains of Staphylococcus epidermidis and 6 （4. 1%） strains of Staphylococcus hemolytic. Of the main gram-negative bacteria, there were 16 （11.0 % ） strains of Pseudomonas maltophilia and 11 （7.6 %） strains of Escherichia coli. The drug resistance rates of the gram-positive bacteria to clarithromycin and linezolid were relatively low, and the drug resistance rates of the gram-negative bacteria to imipenem, amikacin and meropenem were relatively low. CONCLUSION It is necessary for the patients with the infectious endocarditis to reasonably choose antibiotics based on the species of the pathogens so as to reduce the drug resistant strains.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第6期1442-1444,共3页
Chinese Journal of Nosocomiology
关键词
感染性心内膜炎
病原菌
耐药性
Infectious endocarditis
Pathogen
Drug resistance
