摘要
目的 探讨感染性心内膜炎（IE）患者的临床特点,病原菌分布及药物敏感情况.方法 回顾性分析首都医科大学附属北京安贞医院2012年1月至2015年3月住院治疗的IE患者的临床资料.结果 共纳入303例临床确诊IE患者,男211例,女92例,年龄（43±16）岁.IE最常见的临床表现是发热（85.5％）和心脏杂音（62.4％）.基础心脏疾病所占比例最高的是先天性心脏病（33.3％）,非风湿性心脏瓣膜病（13.5％）次之.303例患者中274例（90.4％）发现赘生物.链球菌属（44.2％）是IE的主要致病菌,葡萄球菌（28.9％）位居第二,革兰阴性菌（7.7％）分布呈多样性.革兰阳性球菌对万古霉素（100.0％）和利奈唑胺（97.7％）保持良好的敏感性.结论 先天性心脏病是导致IE的主要基础心脏疾病.链球菌属依然是IE最常见的致病菌.革兰阳性球菌对万古霉素和利奈唑胺保持良好的敏感性.
Objective To investigate the clinical features,pathogenic distribution and drug susceptibility of patients with infective endocarditis （IE）.Methods Clinical data of IE patients were collected,who were admitted to Capital Medical University Affiliated Beijing Anzhen Hospital from January 2012 to March 2015.Results Three hundred and three IE patients were enrolled with age of （43 ± 16）years old.Fever （85.5%）and cardiac murmur （62.4%）were the most common clinical presentations.Congenital heart diseases was the leading underlying diseases in IE patients.Non rheumatic valve diseases （13.5%） followed.Vegetations were found in 90.4% （274/303） patients.Streptococcus which accounted for 44.2% was the major pathogen of IE.Staphylococcus （28.9%） was the second common pathogen.Gramnegative bacteria were diversified in categories.Gram-positive cocci were consistently sensitive to vancomycin and linezolid.Conclusions Congenital heart disease is the main underlying disease related to IE.Streptococcus is still the primary pathogen.Gram-positive cocci keep good sensitivity to vancomycin and linezolid.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2016年第10期774-778,共5页
Chinese Journal of Internal Medicine
