摘要
观察泻心汤对正常、四氧嘧啶 (AL X)致糖尿病 (DM)小鼠及地塞米松致胰岛素抵抗 (IR)、糖耐量减退 (IGT)、模型大鼠的影响。结果表明 :泻心肠能拮抗 AL X诱导的小鼠高血糖 ,明显降低正常小鼠 AL X- DM模型小鼠的空腹血糖 (FBG) ,改善地塞米松致 IR大鼠模型的 IGT,降低病鼠的 FBG及口服葡萄糖 (OGTT)后 2 h血糖 (2 h BG)。
Effects of Xiexin Tang on the level of blood glucose in serial animal models of normal and diabetes mellitus were studied,and its mechanism on reducing blood glucose were preliminarily explored.Fasting blood glucose(FBG) in normal mice,alloxan induced hyperglycemia or diabetes mellitus (DM),two hours blood glucose (2hBG) after oral glucose tolerance test(OGTT)in rats by dexamethasone(DX) induced insulin resistance (IR) and impaired glucose tolerance(IGT) were determined.Results showed the formula can inhibit the hyperglycemia by ALX induced mice,decrease level of FBG in normal and DM mice obviously,improve IGT by DX induced IR rats,reduce FBG and 2hBG after OGTT.The formula has a similar hypoglycemic action of metformin and gliclazide.
出处
《中国实验方剂学杂志》
CAS
2000年第4期33-35,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
:广东省中医药管理局资助课题 !(No972 79)
