摘要
【目的】从血液流变学角度观察桃红四物汤预防股骨粗隆间骨折早期深静脉血栓形成的临床疗效。【方法】采用前瞻随机对照临床试验设计方法,根据一般情况及Evens分型将60例股骨粗隆间骨折早期病例按照分层随机化的方法以1∶1比例分成试验组和对照组各30例。根据《中国骨科大手术静脉血栓栓塞症预防指南》,2组予以相同的综合预防方案,同时试验组予以桃红四物汤,每日1剂,连续7 d。分别观察2组受试对象试验前、试验后血液流变学及伤肢彩色多普勒超声检查结果变化情况。【结果】2组患者一般情况及Evens分型比较差异均无统计学意义(P>0.05)。2组患者试验前血液流变学结果比较,差异均无统计学意义(P>0.05);试验后2组均显著改善(与试验前比较,P<0.05或P<0.01),且试验组的改善作用显著优于对照组,差异均有统计学意义(P<0.05)。试验组试验后伤肢深静脉血栓(DVT)发生率显著低于对照组,差异有统计学意义(P<0.05)。【结论】根据《中国骨科大手术静脉血栓栓塞症预防指南》制定综合预防方案,同时配合桃红四物汤活血化瘀,能够改善股骨粗隆间骨折早期血液流变学状态,预防伤肢深静脉血栓形成,值得临床推广应用。
Objective To observe the clinical effects of Taohong Siwu Decoction on preventing deep vein thrombosis （DVT） in femoral intertrochanteric fracture patients at earlier period by investigating the changes of hemorheology. Methods The prospective, randomized and controlled clinical trial design was adopted. According to the general condition of the patients and Evens classification results, 60 cases were divided into experimental group and control group in accordance with the method of stratified randomization at proportion of 1 ： 1. According to China Prevention Guideline for Venous Thromboembolism After Major orthopedic Operation, the two groups received the same comprehensive prevention program. Simultaneously, the experimental group was treated orally with Taohong Siwu Decoction once daily for 7 days. Hemorrheologic outcome and color Doppler ultrasonography for deep veins of the injured limb were examined in both groups before and after treatment. Results There were no statistically significant differences in general conditions and Evens classification between experimental group and control group （ P 〉 0. 05 ）. The hemorrheologic outcome was similar in both groups before treatment （ P 〉 0. 05 ）. After treatment, hemorrheologic outcome and the results of color Doppler ultrasonography in the experimental group differed from those in the control group （P 〈0. 05 or P 〈0. 01 ）. The improvement in the experimental group was superior to that in the control group （ P 〈 0.05 ）. The experimental group had lower DVT incidence than the control group （P 〈 0. 05 ）. Conclusion Based on medication of the prevention guideline, the combination of comprehensive prevention program and blood-activating and stasis-removing Taohong Siwu Decoction is effective on improving the hemorrheologic outcome of femoral intertrochanteric fracture patients at earlier period, and is benefit to the prevention of deep vein thrombosis in the injured limb.
出处
《广州中医药大学学报》
CAS
北大核心
2013年第2期140-144,共5页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
股骨粗隆间骨折
并发症
深静脉血栓形成
预防和控制
桃红四物汤
治疗应用
血液流变学
Femoral intertrochanteric fracture/complications
Deep vein thrombosis/prevention ＆ control
Taohong Siwu Decoction/therapeutic use
Hemorheology
