摘要
目的探讨血清vaspin(内脏脂肪特异性丝氨酸蛋白酶抑制剂)水平与冠心病及冠状动脉病变程度的相关性。方法选择172例胸部不适的患者进行冠状动脉造影并评价冠状动脉病变程度,按照造影结果分为冠心病组及对照组。记录患者一般情况及血脂,采用ELISA方法测定血清vaspin水平,并进行多因素logistic回归分析。结果冠心病组血清vaspin水平(0.56±0.71)μg/L较对照组(1.18±3.46)μg/L明显降低(P<0.01)。在冠心病患者中冠状动脉病变高积分组血清vaspin水平明显低于低积分组。多因素回归分析显示血清vaspin水平是冠心病的独立相关因素。结论冠心病患者血清vaspin水平较低,血清vaspin水平与冠状动脉病变程度相关。
[ Objective ] To investigate the association of vaspin serum concentration with coronary heart disease and severity of coronary artery lesion. [Methods] 172 patients underwent coronary angiography due to chest pain were studied, the severity of coronary artery lesion was assessed according to coronary angiography analysis. Patients were divided into the coronary heart disease group and the control group according to the result of CAG. Clinical pa- rameters, lipid profile were assayed, vaspin serum level was measured by enzyme-linked immunosorbent assay, mul- tivariate logistic regression analysis was performed. [Results] Serum levels of vaspin were significantly lower in coronary heart disease group （0.56±0.71）μg/L compared to those in control group （1.18±3.46）μg/L. Vaspin serum levels in the higher coronary lesion scores were lower than that of low coronary lesion scores （P 〈0.01） in the CAD group. Logistic regression analysis showed that serum vaspin levels was a independent factor of coronary heart disease.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2012年第33期72-75,共4页
China Journal of Modern Medicine
关键词
冠心病
内脏脂肪特异性丝氨酸蛋白酶抑制剂
冠状动脉病变积分
Vaspin serum concentration were decreased in patients with CAD. Vaspin level correlated with severity of coronary artery lesion.
