摘要
目的:探讨Ki-67和细胞周期依赖性激酶4(CDK4)在宫颈癌及宫颈上皮内瘤变(CIN)中的表达及临床意义。方法:用免疫组织化学染色的方法对152例宫颈组织(22例慢性宫颈炎、52例CIN和78例宫颈癌)进行检测,计算阳性率并进行检验分析。结果:宫颈癌和CIN组织中CDK4阳性率分别为87.2%、59.6%,宫颈癌和CIN组织中Ki-67阳性率分别为95.9%、65.4%。CDK4表达与宫颈癌组织分级、病理分期及淋巴结转移有关(P<0.05)。Ki-67表达与宫颈癌组织分级、病理分期有关(P<0.05)。两者在各组中的表达呈显著正相关(P<0.05)。结论:Ki-67和CDK4可能在宫颈癌的发生、发展中起重要作用,测定宫颈中PTEN可作为宫颈癌的高危人群筛选指标,Ki-67与CDK4检测还可作为宫颈癌的预后指标。
Objective：To investigate the expression and meaning and clinical significance of Ki-67 and cycling dependent kinase （CDK4） in cervical intraepithelial neoplasia and cervical cancer. Methods：CDK4 expression was determined by immunohistochemical staining in 152 cervical specimens （22 cases of chronic cervicitis,52 cases of CIN and 78 cases of cervical cancer）,and its positive rate were analyzed. Results：The positive rate of CDK4 expression in uterine cervix cancer tissue and CIN tissue was 87.2% and 59.6% respectively. The positive rate of Ki-67 expression in uterine cervix cancer and CIN tissue was 95.9% and 65.4% respectively. The expression of CDK4 was correlated with the pathological staging and tissue grading and Lymph transfer of the cervical cancer （P〈0.05）.The expression of Ki-67 was correlated with the pathological staging and tissue grading of the cervical cancer P〈0.05）.The expression of CDK4 was positive correlated with the expression of Ki-67 in CIN and cervical cancer. Conclusion：CDK4 and Ki-67 may play an important role in the pathogenesis and development of cervical squamous cell cancer,and CDK4 and Ki-67 can be used as the indexes for screening high risk population of cervical cancer,which can also be used as the indexes for evaluating the prognosis of patients with cervical cancer.
出处
《中外医学研究》
2013年第6期48-50,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
