摘要
目的 :探讨慢性阻塞性肺病 (COPD)患者血清血管紧张素 (A 、A )和醛固酮水平变化 ,相互间关系及其临床意义。方法 :采用放射免疫法测定了 76例 COPD患者和 30例健康对照组的血清血管紧张素 (A 、AII)和醛固酮 (ALD)水平 ,并进行统计分析。结果 :COPD组 A (2 .73± 0 .0 3ng/ LtALD(132 .2 6± 9.15ng/ L)水平显著高于对照组 (1.4 5± 0 .18ng/ L) 47.15± 2 .2 1n/ L) (t=2 .6 0 2 ,p<0 .0 5;t=4 .189,p<0 .0 1) ,A 水平无显著差异。 37例合并呼吸衰竭组血清 ALD水平显著高于 39例无呼吸衰竭组 p<0 .0 5) ;8例住院期间死亡者血清 ALD也显著高于好转出院者 (P<0 .0 5)。COPD患者中 ,血清 A 、AII和 ALD间呈显著正相关 (P均 <0 .0 5)。结论 :COPD患者存在着明显的 AI、AII和ALDII水平变化 ,而且三者间存在着一定的联系 ,测定其水平有助对 COPD患者病情严重程度和预后的判断。
Objective:[WT5BZ]Studing the changes of the serum angiotensin Ⅰ(A Ⅰ)、angiotensin Ⅱ(A Ⅱ ) and aldosterone (ALD) levels in patients with COPD,and detecting its clinical significiance.[WT5HZ] Methods:[WT5BZ]The serum A Ⅰ、A Ⅱ and ALD levels were detemined by radioimmunoassay in 76 patients with chronic obstruct pulmonary diseases (COPD) and 30 healthy individual.[WT5HZ]Results:[WT5BZ]The results showed that mean serum AⅠ(2,73±0 30ng/L) and ALD (132 26±9.15ng/L) level in patients with COPD was significantly higher than those in healthy in dividual(1.45±0.18ng/L)(47.15±±2.21ng/L)(t=2.602,p<0.05,t=4.189,p<0.01),but the mean serum A Ⅱ(56.54±4.32ng/Lvs 42.90±3.40ng/L)level were no difference(p>0.05).There were showed positive correlated between A Ⅰ and A Ⅱ(r=0.610,p<0.01),A Ⅰ and ALD(r=0.286,p<0.05),A Ⅱ and ALD(r=0.338,p<0.05).In COPD patients with respiratory failure,the mean level of the serum ALD was significantly higher than in patients without respiratory failure.And in died COPD patients,the mean level of the serum ALD was significantly higher than in healing patients.[WT5HZ]Conclusions:[WT5BZ]It may be aided to estimate the prognosis,and to study the pathological mechanism by detemining the levels of the serum A ⅠA II 、and ALD levels in patients with COPD [WT5HZ]
出处
《河北医学》
CAS
2000年第11期969-971,共3页
Hebei Medicine
关键词
慢性阻塞性肺疾病
血管紧张素
醛固酮
Chronic obstruct pulmonary diseases (COPD)
Angiotensin Ⅰ
Angiotensin Ⅱ
Aldosterone
