摘要
目的研究内脂素、抵抗素与男性2型糖尿病患者骨密度及骨代谢指标关系。方法收集我院就诊的男性2型糖尿病患者225例,根据体重指数分为肥胖组107例及非肥胖组118例,对照组为120例非糖尿病正常男性。体格检查计算腰臀比(WHR)及体重指数(BMI),酶联免疫法(ELISA)测定血清内脂素、抵抗素水平,双能X线骨密度仪测定腰椎(L2-L4)及左股骨颈骨密度。结果肥胖糖尿病组BMI及WHR高于其他组(P<0.05);肥胖及非肥胖糖尿病组的内脂素、抵抗素水平高于对照组(P<0.05),且肥胖组高于非肥胖组(P<0.05)。肥胖及非肥胖糖尿病组的BGP、CTX-1水平低于对照组。非肥胖糖尿病组腰椎及股骨颈骨密度明显低于正常组与肥胖组(P<0.05),且肥胖组的腰椎骨密度高于对照组,但股骨颈骨密度两组间无明显差异(P>0.05)。直线相关分析显示BMI、WHR、内脂素、抵抗素均与BGP、CTX-1负相关,BMI及WHR与腰椎及股骨颈骨密度正相关,内脂素、抵抗素与腰椎骨密度呈正相关(P<0.05),但与股骨颈骨密度无明显相关(P>0.05)。结论血清内脂素、抵抗素水平与男性2型糖尿病患者骨代谢水平及腰椎骨密度相关。
Objective To investigate the relationship among visfatin, resistin, bone mineral density, and bone metabolism in male patients with type 2 diabetes. Methods A total of 225 male patients with type 2 diabetes, who received the treatments in our hospital, were selected. They were divided into obesity group （n = 107） and non-obesity group （n = 118） according to the body mass index （BMI）. One hundred and twenty healthy men were in control group. BMI and waist-to-hip ratio （WHR） were calculated after physical examination. Serum levels of visfatin and resistin were tested using ELISA. Bone mineral density （BMD） of the lumbar vertebrae （L2 -4） and the left femoral neck was detected using DXA. Results BMI and WHR of patients in obesity group was significantly higher than those in other groups （P 〈 0. 05 ）. Serum levels of visfatin and resistin of patients in both obesity and non - obesity groups were higher than those in control group （P 〈 0.05） , and they were much higher in obesity group than those in non-obesity group （P 〈 0.05）. The serum levels of BGP and CTX-1 of patients in both obesity and non-obesity groups were significantly lower than those in control group （ P 〈 0.05 ）. BMD of the lumbar vertebrae and the femoral neck of patients in non-obesity group was lower than that in obesity group and control group （ P 〈 0.05 ）. BMD of the lumbar vertebrae in obesity group was higher than that in control group （ P 〈 0. 05 ） , but BMD of the left femoral neck in both obesity and control groups showed no significant difference （P 〉 0. 05）. Linear correlation showed that BMI, WHR, visfatin and resistin were all negatively correlated with BGP or CTX-1 （P 〈 0. 05）. BMI and WHR were positively correlated with the BMD of the lumbar vertebrae and the leftfemoral neck （ P 〈 0. 05 ）. Visfatin and resistin were positively correlated with the BMD of the lumbar vertebrae （P 〈0. 05）, but they were not correlated with the BMD of the left femoral neck （P 〉 O. 05）. Conclusion Serum levels of visfatin and resistin are correlated with bone metabolism and BMD of the lumbar vertebrae in male patients with type 2 diabetes
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2013年第2期135-137,157,共4页
Chinese Journal of Osteoporosis
基金
南昌市科技局重点攻关资助项目(洪社会发展支撑计划第53号)
关键词
内脂素
抵抗素
2型糖尿病
骨密度
骨代谢
Visfatin
Resistin
Type 2 diabetes
Bone mineral density
Bone metabolism
