摘要
目的探索骨髓间充质干细胞(BMSCs)移植对去卵巢骨质疏松大鼠骨密度的影响。方法雌性SD大鼠随机分为空白对照组(A组)、模型组(B组)、细胞治疗组(C组)、雷诺昔芬药物治疗组(D组)。通过去卵巢建模成功后,C组通过尾静脉移植BMSCs,D组口服雷诺昔芬抗骨质疏松药物。结果与A组相比,B组腰椎和股骨骨密度均明显降低(P<0.01)。BMSCs治疗后,C组中的骨密度得到明显改善,并与B组比较具有统计学差异(P<0.01),亦优于D组。结论 BMSCs可以有效改善去卵巢大鼠骨质,这为绝经后骨质疏松的治疗提供了一种新的方法,为进一步临床应用提供了实验支持。
Objective To investigate the effect of transplantation of bone marrow mesenchymal stem cells （BMSCs） on bone mineral density in ovariectomized osteoporotic rats. Methods Female SD rats were randomly divided into 4 groups： blank control group （group A） , model group （group B） , cell therapy group （group C）, and Raloxifene treatment group （group D）. The model was established after ovariectomy. Rats in group C received the transplantation of BMSCs via the tail vein. Rats in group D received the oral treatment of anti-osteoporosis drug （ Raloxifene）. Results Bone mineral density （BMD） of the lumbar vertebrae and the femur in group B was significantly lower than that in group A （ P 〈 0. 01 ）. After BMSCs transplantation, BMD in group C was improved obviously, and there was significant difference comparing with that in group B （P 〈 0.01）. And the BMD in group C was higher than that in group D. Conclusion Transplantation of BMSCs can effectively improve the BMD in ovariectomized osteoporotic rats. These results provide a new method for postmenopausal osteoporosis and experimental evidence for further clinical application of BMSCs transplantation.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2013年第2期131-134,共4页
Chinese Journal of Osteoporosis
基金
全军十一五课题(项目编号:06MA303)
关键词
骨髓间充质干细胞
骨质疏松
Bone marrow mesenchymal stem cells
Osteoporosis
