摘要
目的:分析延边地区朝鲜族和汉族男性血清γ-谷氨酰转肽酶(glutamyl transferase,GGT)与多种代谢异常及其聚集的相关性.方法:于2009-07/2010-07在延边地区安图县采取整群抽样方法选取30-70岁朝鲜族和汉族男性人群3416例,收集一般特征、吸烟、饮酒等信息,测量身高、体质量、腰围、血压,准确测定清晨空腹(禁食12h)静脉血GGT、血脂及血糖.结果:(1)朝鲜族和汉族男性GGT升高者的检出率分别为26.1%和13.9%(x2=49.004,P<0.01),其年龄调整检出率分别为27.2%和13.8%(U=77.011,P<0.01);(2)单因素分析显示,朝鲜族男性的年龄、饮酒、高血压、高TC血症、高TG血症、低HDL-C血症、整体型肥胖、腹型肥胖及MS与GGT升高有关联,汉族男性的文化程度、吸烟、饮酒、高血压、高TC血症、高TG血症、腹型肥胖及MS与GGT升高有关联;(3)多因素Logistic回归分析显示,本地区男性的年龄、饮酒、高血压、腹型肥胖、高TC血症、高TG血症、MS和民族(朝鲜族)与GGT升高呈正相关,其中年龄和饮酒频率对GGT升高的影响具有剂量反应关系;(4)朝鲜族与汉族男性GGT升高者检出率均随着多种代谢异常聚集程度的增加呈增加趋势,其增加趋势有统计学意义(P<0.01).结论:(1)本地区朝鲜族男性GGT升高检出率明显高于汉族;(2)本地区男性GGT升高与多种代谢异常及其聚集密切相关,且随着多种代谢异常聚集程度的增加呈增加趋势.
AIM： To analyze the relationship between serum levels of gamma-glutamyl transferase （GGT） and multiple metabolic disorders and their clustering in Korean and Han men in Yanbian rural areas.METHODS： A population-based cross-sectional study was conducted. In total, 3 416 subjects, ranging in age from 30 to 70 years, were included. The height, weight, waist circumference and blood pressure were measured. Serum levels of GGT, lipids and glucose were measured after a 12-hour fast.RESULTS： The detection rate of elevated GGT was 26.1% in Korean and 13.9% in Han men, and the age-adjusted detection rate was 27.2% and 13.8%, respectively, which showed a significant ethnic difference. Univariate analysis showed that elevated GGT in Korean men was correlated with age, drinking, hypertension, high TC, high TG, low HDL-C, general obesity, central obesity and MS, while elevated GGT in Han men was correlated with education level, smoking, drinking, hypertension, high TC, high TG, central obesity and MS. Multivariate logistic analysis showed that elevated GGT was closely related with age, drinking, hypertension, central obesity, high-TC, high-TG, MS and nationality, and dose-response relationship was seen between elevated GGT and age and drinking. The prevalence of elevated GGT increased with the increase in the number of metabolic disorders in both nationalities.CONCLUSION： There was a significant difference in the prevalence of elevated GGT between Korean and Han men. Elevated GGT was closely related with multiple metabolic disorders and their clustering.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第2期153-159,共7页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
Nos.30260098
30860244
吉林省教育厅基金资助项目
No.2008-2~~
关键词
Γ-谷氨酰转肽酶
代谢异常
相关性
民族
Gamma-glutamyl transferase
Metabolic disorder
Relationship
Nationality
