摘要
目的探讨P300/CBP相关因子(PCAF)在肝癌中的表达情况以及临床意义。方法采用免疫组化技术检测35例手术切除肝癌组织及相应癌旁肝组织中PCAF的表达情况。采用χ2检验检测PCAF蛋白的表达和临床资料间的相关性,采用Kaplan-Meier Log Rank检验进行单因素生存分析,采用Cox回归模型进行多因素分析。结果 PCAF蛋白在癌旁肝组织与肝癌组织中的表达具有显著性差异(P<0.05),并且与肿瘤TNM分期以及肿瘤转移相关(P<0.05)。COX多因素分析表明,肝癌患者术后导致较差预后的独立影响因素包括PCAF表达降低、更高的肿瘤TNM分期以及肿瘤转移。结论肝细胞癌中的PCAF表达下调,并且与预后相关。PCAF有可能成为肝癌重要的生物学标志。
Objective To investigate the expression of P300/CBP-associated factor （PCAF） in hepatocellular carcinoma （HCC） and its clinical significance. Methods Immunohistochemistry was performed to evaluate the expression of PCAF in HCC tissues and adjacent normal liver tissues of 35 HCC patients. We analyzed the correlation between the expression of PCAF and clinical data using chi-square test, and then anaylzed the factors which affected survival by Kaplan-Meier Log-rank test and multivariate Cox regression model. Results The expression of PCAF in the HCC tissues was significantly different from that in the adjacent liver tissues （ P 〈 0.05） and it was correlated with tumor TNM staging and tumor metastasis （ P 〈 0. 05）. Multivariate COX regression analysis showed that the independent factors predicting poor long-term HCC survival after radical liver resection included low PCAF expression, advanced TNM stage and tumor metastasis. Conclusion PCAF expression is down-regulated in HCC and constitutes a promising biomarker for the prognosis after curative liver resection.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2013年第3期297-300,共4页
Chinese Journal of Cellular and Molecular Immunology
基金
国家自然科学基金(81071897)
西安交通大学医学院第一附属医院"临床医学专业七年制学生临床创新科研基金"(12YB03)
