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副肿瘤性边缘叶性脑炎1例报道及文献复习 被引量：2

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摘要 目的报道1例临床上罕见的副肿瘤性边缘叶性脑炎(paraneoplastic limbic encephalitis,PLE)女性患者的临床资料,复习相关文献分析并探讨其临床特点。方法临床观察1例PLE患者的临床表现、脑脊液、头颅MRI、脑电图、肿瘤病检等方面资料并进行了探讨。结果患者呈亚急性起病,病情进行性加重,临床表现以精神神经症状为主并先于肿瘤的发现,头颅MRI未提示特异性改变,脑脊液检查可见白细胞明显增加,蛋白轻度增加,氯化物轻度降低,脑电图提示有阵发性散在慢波发放,肿瘤病检示左侧卵巢未成熟畸胎瘤和右侧卵巢囊性畸胎瘤。予抗癫、营养神经对症治疗及肿瘤切除后,患者症状有所缓解。结论副肿瘤性边缘叶性脑炎是一种罕见的神经系统副肿瘤综合征(paraneoplastic neurological syndrome,PNS),由于缺乏特异性诊断标志,且往往以神经精神症状为首发症状,临床诊断存在一定困难,容易误诊。因此需要提高对该病的认识,早期发现原发肿瘤有助于诊断治疗。
作者 陈光希 张兆辉
机构地区 武汉大学人民医院神经内科
出处 《卒中与神经疾病》 2013年第1期29-31,共3页 Stroke and Nervous Diseases
关键词 神经系统副肿瘤综合征 副肿瘤性边缘叶性脑炎 边缘叶性脑炎 畸胎瘤
分类号 R758.66 [医药卫生—皮肤病学与性病学]
  • 相关文献

参考文献15

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二级参考文献20

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卒中与神经疾病
2013年 第1期

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