摘要
目的 本文对细菌 L型感染诱发小鼠肿瘤的可能原因进行了探讨。方法 用金黄色葡萄球菌 L型 (2× 10 7/0 .2 ml/次 /只 )经尾静脉反复感染 C5 7/ BL / 6 N小鼠为 L型感染组 ;注射生理盐水的小鼠为对照组。结果 L型感染组有 10只小鼠发生肿瘤 ,肿瘤发生率为 11.1% ,其中恶性肿瘤 8.88% (8只 ) ;良性肿瘤 2 .2 2 % (2只 )。感染组小鼠体细胞增生和不典型增生11.1% (10只 ) ;瘤样增生 3.33% (3只 ) ,而对照组均未发生肿瘤和增生性病变。结论 L 型菌感染可能与小鼠体细胞增生、不典型增生和肿瘤发生关系密切。
Aim\ To detect the possible relationship between the L-form bacterial infection and tumor.Method\ Mice wer intravenously infected with L-form of staphylococcus aureus with dosage of 2×10 in 0.2 ml each mouse.Normal saline was used instead of staphylococcus aureus as control.Result\ Tumors were found in 10 mice(11.1%)infected with L-form of S.aureus,8 of the 10 had malignant tumors (888%),and 2 had benign ones(2.22%).The hyperplasia and dysplasia hyperplasia of somatic cells of the infected group were found in the mice(11.1%),and tumor-like hyperplasia was found in 3 mice(3.33%).No mabnormal pathological change was found in the control group.Conclusion\ Devenlopment of tumor and dysplasia hyperplasia may be closely related to the bacteria-form infection.
出处
《中国人兽共患病杂志》
CSCD
北大核心
2000年第6期37-38,F003,共3页
Chinese Journal of Zoonoses
基金
安徽省教委重点科研究项目!资助批准号 97JL14 7Z
关键词
金葡菌L型感染
不典型增生
肿瘤
Staphylococcus aureus L-form
dysplasia hyperplasia
tumor
