摘要
目的评价在使用促性腺激素释放激素激动剂(GnRH-a)进行垂体降调节后,出现慢反应的患者补充重组黄体生成素(rLH)的有效性。方法本研究以应用GnRH-a长方案进行垂体降调节后,对卵泡刺激素(FSH)刺激呈慢反应的患者为研究对象,在卵巢刺激第7～8天补充rLH 75～150 U/d,至注射人绒毛膜促性腺激素(HCG)日。观察卵泡发育情况、雌二醇(E_2)水平、获卵数、以及HCG阳性率和临床妊娠率等。结果自2009年12月至2011年8月,共计60例符合慢反应诊断标准的患者在促排卵过程中补充了rLH,所有研究对象均接受了HCG注射和取卵。每个刺激周期的获卵数为(12.4±7.2)个,成熟卵母细胞数为(9.6±6.5)个,获得的胚胎数为(6.4±4.6)个。54例(90%)患者进行了新鲜胚胎的移植。每个刺激周期的HCG阳性率为56.7%,临床妊娠率为55.0%,卵巢过度刺激综合征(OHSS)的发生率为3.3%(2例,均为轻度)。结论对FSH刺激呈慢反应的患者补充rLH可以改善卵巢的反应性,增加获卵数,改善妊娠结局。
Objective： To evaluate the effect of recombinant LH （rLPl）on in vitro Iernnzanon （IVF） outcome in women with slow response to recombinant FSH（rFSH）after pituitary down regulation with gonadotropin- releasing hormone agonist（GnRH-a）. Methods： This is a multiple center, prospective and observational study. Women with slow response to rFSH after pituitary down regulation by GnRH-a long protocol were given rLH 75 U/day to 150 U/day from the seventh or eighth day of ovarian stimulation until the day of HCG administration. Follicle development, serum estradiol （E2）level, number of oocyte retrieved, pregnancy rate, as well as the satisfaction of patients to artificial reproductive technology（ART）treatment and incidence of adverse events were evaluated. Results： Sixty patients were eligible for this study from Dec 2009 to Aug 9.011. The number of oocytes retrieved per stimulation cycle was 12.4 ±7.2, the number of mature oocytes was 9.6±6.5 and the number of embryos obtained was 6.4±4.6. Fifty four（90%）patients received fresh embryo transfer. The HCG positive rate per stimulation cycle was 56.7%, and the clinical pregnancy rate was 55.0%. Conclusions： rLH supplementation may improve IVF outcome in women with slow response to rFSHstimulation after pituitary down regulation with GnRH-a.
出处
《生殖医学杂志》
CAS
2013年第2期92-96,共5页
Journal of Reproductive Medicine
关键词
控制性卵巢刺激
体外受精-胚胎移植
慢反应
重组黄体生成素
In vitro fertilization-embryo transfer
Controlled ovarian stimulation
Slow response
Recombinant luteinizing hormone
