摘要
目的 :探讨葡胺聚糖 (GAGs)对尿石形成的影响。方法 :采用透析法从 10例上尿路草酸钙结石患者及 11例正常人尿中制备 GAGs,经蛋白水解酶 Pronase E消化后 ,用咔唑试剂反应法测其 GAGs含量。结果 :结石患者尿GAGs浓度低于正常人 (P<0 .0 1) ,分别为 6 .0 8mg/ L± 1.39m g/ L和 8.80 m g/ L± 1.92 m g/ L ,2 4h排泄量分别为 13.5 8m g± 3.18mg和 14.94mg± 3.85 mg,两组间无显著性差异。结论 :尿 GAGs浓度减低与尿石形成有关 ,外源性提高尿 GAGs浓度 ,可望预防尿草酸钙结石形成及复发。
Objectives:To study the effects of glycosaminoglycans (GAGs) on urinary stone formation.Methods:GAGs was extracted from urine of 10 calcium oxalate stone-formers and 11 normal subjects by dialysis,after hydrolysis with Pronase E,the GAGs was measured by the method of carbazole reaction.Results:The urinary GAGs concentration of stone patients was significantly lower than that of normal subjects ( P <0.01).Conclusions:Low urinary GAGs concentration may be an important element in calcium oxalate stone formation.
出处
《山西临床医药》
2000年第10期747-748,共2页
Shanxi Clinical Medicine
