摘要
以含有杂原子的生物素、硫辛酸、异烟酸和姜黄素为原料,以二步酰氯法合成了姜黄素生物素酯、姜黄素硫辛酸酯、姜黄素异烟酸酯。经红外,核磁共振氢谱和质谱确证了化合物的结构。在相同条件下,以姜黄素为对照测定了产物对金色葡萄球菌的抑菌性能。结果显示,姜黄素硫辛酸酯、姜黄素生物素酯、姜黄素异烟酸酯三种姜黄素衍生物在抑菌活性上均有不同程度的增强,最小抑菌浓度(MIC)分别为2.5、5.0、5.0 mg/mL,在最小抑菌浓度下抑菌圈分别为10、10、8 mm。
Curcumin derivatives were synthesized with biotin, lipolic acid, isonicotlnic acid and curcumin, using the acylchloride method. Their chemical structures were confirmed by IR, MS and 1H-NMR spectroscopy. The antimicrobial activities of these new compounds were explored with Staphylicoccus aureus under the same conditions compared with cur- cumin. The results showed that the antimicrobial activities of these new compounds were better than curcumin, the MICs were 2.5,5.0,5.0 mg/mL. The diameters of inhibition zone of each products were 10,10,8 mm.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2013年第2期237-240,共4页
Natural Product Research and Development
基金
山东省自然科学基金项目(ZR2010BM021)
关键词
生物素姜黄素酯
硫辛酸姜黄素酯
异烟酸姜黄素酯
金色葡萄球菌
抑菌活性
biotin curcumin ester
lipoic curcumin ester
isonicotinic curcumln ester
Staphylicoccu aureua
antimicrobialactivities
