摘要
目的:探讨参精扶正方防治食管癌放疗所致骨髓抑制的临床疗效。方法:将70例行单纯放疗的食管癌患者随机分成观察组和对照组各35例,对照组放疗起始口服利血生,20 mg/次,3次/d。观察组口服参精扶正方,1剂/d。两组疗程均到放疗结束。观察骨髓抑制情况及生活质量。结果:治疗后14,21,28,35,42 d观察组外周血白细胞WBC计数均高于对照组(P<0.01);观察组出现Ⅲ度骨髓抑制例数少于对照组(P<0.05),出现时间晚于对照组(P<0.01);治疗后观察组血红蛋白、血小板和粒细胞水平均高于对照组(P<0.01);观察组临床症状积分低于对照组(P<0.01);观察组Karnofsky评分高于对照组(P<0.05);观察组欣粒生用量少于对照组(P<0.01)。结论:参精扶正方能防治食管癌放疗所致骨髓抑制,减轻临床副反应,提高患者生活质量。
Objective：To investigate the prevention and treatment effect of pre-treatment of Shenjing Fuzheng prescription （SFP） for bone marrow suppression induced by radiotherapy in patients with esophageal cancer. Method： Seventy patients suffered from esophageal cancer with routine radiotherapy were randomized into observation group and control group （n=35 each）. The controls were orally given leucogen 20 mg tid daily parallel to radiotherapy. The patients in the observation group were given SFP daily parallel to radiotherapy. The interventions in the two-group were lasted until the end of radiotherapy. Bone marrow suppression and quality of life were evaluated. Result： WBC count levels in the observation group on 14, 21, 35, 42 d were higher than those in control group （P〈0.01）. The cases of III degree bone marrow suppression in the observation group appeared less than that in the control group （P〈0.05）, and with delayed duration of emerging （P〈0.01）.In the observation group, hemoglobin, platelet count and granulocyte count were higher than those in the controls （P〈0.01）; clinical symptoms scores were lower than that in the controls （P〈0.01）; and Karnofsky score higher than that in the controls （P〈0.05）. In the observation group, the consume of recombinant human granulocyte colony stimulating factor was less than that in the controls （P〈0.01）. Conclusion： SFP can be used for prevention and treatment of bone marrow suppression caused by radiotherapy in esophageal cancer, and reduce the clinical side effects, improve patients＇ quality of life.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第5期330-332,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
食管癌
放疗
骨髓抑制
参精扶正方
生活质量
esophageal cancer
radiotherapy
bone marrow suppression
Shenjing Fuzheng prescription
quality of life
