摘要
目的 探讨视网膜厚度分析仪 (retinalthicknessanalyzer,RTA)对青光眼的诊断价值。方法 应用RTA测定 77例 ( 116只眼 )各年龄组正常人及 2 2例 ( 35只眼 )青光眼患者眼后极部视网膜厚度 ,并将图像经计算机处理后 ,得到该处视网膜的厚度值和厚度地形图 ,所得数据用SAS统计软件包进行分析。结果 正常人平均视网膜厚度为 ( 171 83± 18 5 0 ) μm ,各年龄组间差异无显著性 (F=2 6 8,P >0 0 5 ) ;性别间差异亦无显著性 ;黄斑与视乳头间视网膜最厚 ,黄斑鼻侧较颞侧厚 ;黄斑上下方基本对称。青光眼患者的视网膜呈弥漫性或局限性变薄 ,与正常人视网膜厚度比较 ,差异有非常显著性 (F =11 98,P =0 0 0 0 1) ,RTA检查对青光眼诊断的敏感性达 80 8% ,特异性达 78 5 %。结论正常人眼后极部视网膜厚度地形图呈马蹄形 ,与视神经节细胞及其视神经纤维的解剖位置相吻合。青光眼患者的视网膜呈弥漫性或局限性变薄改变 ,与相应的视野改变相吻合 ,视网膜厚度检测的敏感性较视野检测高。RTA检查操作简便、重复性强 ,无创伤性 。
Objective To determine the diagnostic value of retinal thickness analyzer (RTA) in glaucoma Methods RTA was used to measure the retinal thickness at the posterior pole in 77 normal persons (116 eyes) at various ages and 22 cases (35 eyes) with glaucoma The obtained images were processed by a computer to yield the retinal thickness value and the thickness map at this location, and the data were analyzed with SAS software package Results The mean retina thickness of normal subjects was (17183±1850) μm with no significant difference among the various age groups (F=268,P>005), and very significant between the sexes; the thickest retina was at the location between macula and optic nerve head, and the macular nasal retina is 117% thicker than its temporal side The upper and lower retinas of the fovea were basically symmetrical The retinal thickness in glaucoma patients showed diffuse or local thinning, and there was a very significant difference between the normal group and the glaucomatous group in retina thickness (F=1198,P=0000 1) The sensitivity rate for detecting glaucoma with RTA was up to 808%, and specificity to 785% Conclusions The thickness map for the retina at posterior pole across the macula in normal subjects is “horse shoe” shaped, that is well matched with the topography of retinal ganglion cell and the retinal nerve fibers in human retina Diffuse or local thinning of retinal thickness in glaucomatous patients, which is in agreement with the corresponding visual field defect, and the sensitivity of RTA is higher than that of perimeter The RTA examination is easy to operate, has high reproducibility, no invasion, therefore it is an ideal method to measure the human retinal thickness in vivo
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2000年第2期124-128,I011,共6页
Chinese Journal of Ophthalmology
关键词
视网膜厚度
分析仪
青光眼
诊断
Retinal thickness analyzer
Glaucoma
Diagnosis
