摘要
目的解决《中国药典》2010年版中甲基纤维素动力黏度测定法中存在的问题。方法本实验采用同轴圆筒式旋转流变仪考察了剪切速率、测定温度、屈服值和触变性等对样品流变学性质的影响,确定了测定样品的最佳温度和剪切速率。结果通过实验确定测定温度为(20±0.1)℃,剪切速率为80s-1。结论该方法简便、准确、重现性好,适用于甲基纤维素黏度的测定。
OBJECTIVE To solve the existing problems of the determination method of dynamic viscosity of methylcellulose in Chinese Pharmacopoeia（2010 edition）. METHODS By virtue of concentric cylinder rheometer, the experiment probes into the influ- ence of shear rate, temperature measurement, the yield value, thixotropic, etc. on the rheological properties of samples, and identifies then the optimum temperature and shear rate of the samples. RESULTS The optimum conditions were established as temperature of （20 ＋ 0. 1 ） ℃ and shear rate of 80 s-1. CONCLUSION This method is simple and accurate with good repeatability. It can be ap- plied to determine the viscosity of methylcellulose.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2013年第5期385-388,共4页
Chinese Pharmaceutical Journal
基金
国家药典委员会立项课题(1678)
关键词
甲基纤维素
动力黏度
旋转流变仪
methylcellulose
dynamic viscosity
concentric cylinder rheometer
