摘要
对依替米星 (etimicin,ETM)与哌拉西林 (piperacillin,PIPC)兔体合用药动学进行了研究。采用自身交叉试验 ,以微量微生物法 (IMM)检测血、尿中 ETM浓度 ,检测菌为短小芽胞杆菌 ,药时数据经 3P87软件处理。结果证明 :(1)兔体 ETM单用及与 PIPC合用时药时曲线均符合二房室开放模型 ;(2 )单用组和合用组的 V(c)、t1 /2α、t1 /2β、K2 1 、K1 0 、K1 2 、AUC、Cls等药动学参数分别为 :0 .2 738和 0 .2 747L / kg;0 .310 0和 0 .3315 h;1.6 86 5和 1.6 882 h;1.40 81和 1.36 111/ h;0 .6 6 96和 0 .6 6 35 1/ h;0 .6 2 0 7和 0 .5 6 5 6 1/ h;38.32 71和 38.6 410mg·h/ L;0 .1834和 0 .182 3L/ h;(3) 12 h尿药回收率分别为 87.46 %和 87.18%。两组之间其它药动学参数均无显著性差异 (P>0 .0 5 )。表明两药合用时 PIPC对 EMT兔体内的药动学无显著影响 ,具有一定优越性。本结果为临床联合用药提供了依据。
This paper studied the pharmacokinetics of etimicin combine with piperacillin (PIPC) in 10 Japanese white rabits by using a crossover design. The etimicin concentration in blood and urine was detected with modified microbiology method. The tesed microoganism was Bacillus pumilus. The concentration time data were disposed with 3P87 program. The results demonstrated that: (1) The concentration time curve of etimicin in rabbits were adequately fittied to two compartment open model; (2) The parameters such as V(c), t 1/2α , t 1/2β , K 21 , K 10 , K 12 , AUC, Cl s were 0.2738 and 0.2747L/kg; 0.3100 and 0.3315h; 1.6865 and 1.6882h; 1.4081 and 1.3611 1/h; 0.6696 and 0.6635 1/h; 0.6207 and 0.5656 1/h; 38.3271 and 38.6410mg·h/L; 0.1834 and 0.1823 L/h, respectively; (3) The 12h urinary recovery rate of groups were 87.46% and 87.18%, respectively. There was no significant difference (P>0.05) between the parameters of the two groups. The results indicated that PIPC has no apparently effect on the pharmacokinetics of etimicin in the normal rabbits.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2000年第B05期56-58,共3页
Chinese Journal of Antibiotics
