摘要
[目的]探讨STAT3、VEGF-C在甲状腺癌中表达及其与临床病理特征关系。[方法]采用免疫组化SP技术,检测STAT3及VEGF-C在90例甲状腺癌、30例甲状腺腺瘤和瘤旁正常甲状腺组织中表达,分析其与甲状腺癌临床病理特征关系。[结果]在正常甲状腺组织、甲状腺腺瘤组织及甲状腺乳头状癌组织中,STAT3、VEGF-C表达阳性率逐渐增加,其差异均有统计学意义(P<0.01),且两者存在正相关(r=0.704,P<0.01)。STAT3在甲状腺癌中表达在不同患者年龄、肿瘤大小、肿瘤包膜侵犯、淋巴结转移、临床分期及肿瘤多灶性方面差异有统计学意义。VEGF-C在甲状腺癌中表达在不同甲状腺癌大小、肿瘤包膜侵犯、淋巴结转移及肿瘤多灶性方面差异有统计学意义。[结论]对甲状腺癌进行STAT3和VEGF-C检测,有助于判断肿瘤的侵袭和转移情况。
[Purpose] To investigate the expressions of STAT3 and VEGF-C in thyroid carcinoma and Their relationship with clinicopathological characteristics. [Methods] STAT3 and VEGF-C were detected immunohistochemically in thyroid cancer tissues （90 cases） , thyroid adenoma tissues （30 cases） and thyroid tissues adjacent to adenoma. The relationship between STAT3, VEGF-C expressions and clinicopathological characteristics in thyroid cancer was analyzed. [Results] In normal thyroid tissue,thyroid adenoma tis- sue and thyroid carcinoma tissue,positive rates of both of STAT3 and VEGF-C gradually increased,with significant difference （P〈0.01）,and there was a positive correlation be- tween the expressions of the two proteins （r=-0.704,P〈0.01）. The expression of STAT3 in thyroid carcinoma was significantly different for patients with different status of ages,tu- mor sizes, capsular invasion,lymph node metastasis, clinical stages, and multifocus of tu- mor（P〈0.05）. The expression of VEGF-C in thyroid carcinoma was significantly different in patients with different status of tumor sizes, capsular invasion, lymph node metastasis, and multifocus of tumor （P〈0.05）. [Conclusion] Detection of STAT3 and VEGF-C expres- sions in thyroid carcinoma help to predict cancer invasion and metastasis.
出处
《肿瘤学杂志》
CAS
2013年第2期118-121,共4页
Journal of Chinese Oncology
基金
温岭市科技计划资助基金(温科2011wlca0067)
