摘要
目的:探讨食管鳞癌组织中胰岛素样生长因子 -1受体(IGF- 1R)的表达及其与食管鳞癌发生发展的关 系。方法:应用免疫组织化学SP技术,对54例食管鳞癌组织、22例癌旁不典型增生组织和54例正常组织中IGF -1R的表达情况进行检测分析。结果:食管鳞癌组织、癌旁不典型增生及正常组织中IGF- 1R的阳性表达率分别为 92.59%、59.09%和20.37%,3组间两两相比,差异均有统计学意义(P<0.01);3组的强阳性率分别为76.00%、 46.15%和9.09%,3组间两两相比,差异亦均有统计学意义(P<0.05或P<0.01)。结论:IGF 1R在食管鳞癌组 织中高表达与食管鳞癌的发生发展有关。
Aim: To investigate the expression of insulin-like growth factor-1 receptor (IGF-1R) in esophageal squamous cell carcinoma and correlation between IGF-1R and the pathogenesis and development of esophageal squamous cell carcinoma. Methods:The IGF-1R expression in 54 cases of esophageal squamous cell carcinoma, 22 cases of adjacent cancer tissue,and 54 cases of normal esophageal tissue was detected by immunohistochemistry. Results: The positive rates in esophageal squamous cell carcinoma, adjacent cancer tissue and normal esophageal tissue were 92.59%,59.09%,and 20.37%, respectively, and the difference between any two groups was significant(P<0.01); the powerful positive rates in esophageal squamous cell carcinoma, adjacent cancer tissue and normal esophageal tissue were 76.00%, 46.15%, and 9.09%, respectively, and the difference between any two groups was significant(P<0.05 or 0.01). Conclusion: The over expression of IGF-1R in esophageal squamous cell carcinoma is related with pathogenesis and development of the carcinoma.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2005年第2期273-275,共3页
Journal of Zhengzhou University(Medical Sciences)
基金
河南省自然科学基金资助项目 411042500
关键词
胰岛素样生长因子-1受体
食管肿瘤
鳞癌
insulin-like growth factor-1 receptor
esophageal neoplasm,squamous cell carcinoma
