摘要
本文利用卵巢癌手术标本建立体外细胞系及裸鼠移植瘤(OEC)。将来自同一病人的脾淋巴细胞体外经重组人类白细胞介素2活化为LAK细胞。裸鼠体内进行的Winn氏中和试验结果表明,L-AK细胞能有效地抑制自体恶性肿瘤在裸鼠体内的成瘤现象。
Human Ovary Embryo Carcinoma (OEC) removed surgically have been transplanted into nude mi-
ce and cultured in vitro, that would be used as targets. Lymphokine-activated killer cells were gener-
ated from splenic lymphocytes of the OEC patient through co culturc with recombinant human inter-
luekin-2 in vitro. The results of winn's test in nude mice have suggested that the LAK cells could
effectively inhibit the growth of autologous tumors in vivo.
出处
《北京医科大学学报》
CSCD
1991年第6期432-434,共3页
Journal of Peking University(Health Sciences)
基金
美国中华医学基金
关键词
LAK细胞
肿瘤
白细胞介素2
Lymphokine-activated killer cells
Interluekin-2
Nude mice
