摘要
目的:分析碳青霉烯类抗菌药物致药品不良反应(ADR)的特点,为临床合理用药提供参考。方法:检索2007-2012年在中国知网(CNKI)、万方医学网公开发表的碳青霉烯类抗菌药物致ADR的文献,收集到符合条件的文献共106篇,发表的期刊有30种,共有119例患者;对患者的性别、年龄、原发疾病、涉及药品、ADR发生时间、累及器官或系统及临床表现、临床转归情况进行统计、分析。结果:119例患者中男性76例、女性42例,不详1例;61～80岁年龄段患者ADR发生率最高;主要原发疾病为呼吸系统、循环系统、消化系统疾病;涉及到的碳青霉烯类药主要有亚胺培南/西司他丁钠、美罗培南、比阿培南3种;其中用药时间在5h以上发生ADR的患者占全部患者的89.08%;主要的ADR累及神经系统、消化系统及循环系统;94.12%的患者于停药后症状完全消失。结论:临床使用碳青霉烯类药时应监测ADR,以提高用药安全性和合理性,减少ADR的发生。
OBJECTIVE： To analyze the characteristics of carbapenem antibacterial drugs induced adverse drug reactions （ADR）, and to provide foundation for reasonable drug use in the clinic. METHODS： Retried from CNKI and Wanfang database, 106 literalures about carbapenem antibacterial drug-induced adverse drug reactions published from 2007 to 2012 were collected, involving 30 journals and 119 patients. Patient＇s sex, age, primary disease, drug involved, occurrence time of ADR, organs or system involved in ADR and clinical manifestation, and outcome were analyzed statistically. RESULTS： Among 119 patients, there were 76 male and 42 female patients, and one patient was not clear; highest incidence of ADR occurred in patients aged 61-80; respiratory, digestive, circulatory system diseases were main primary disease; carbapenem involved imipenem/cilastatin sodium, meropenem, biapenem; 8!）.08% of patients suffered from ADR with more than 5 h administration; main ADR almost distributed in nerves, digestive and circulatory system; ADR of 94.12% of patients disappeared after withdrawal of the durgs. CONCLUSIONS： ADR should be paid more attention to in clinical practice to improve safety and effectiveness of drug use and reduce the occurrence of ADR.
出处
《中国药房》
CAS
CSCD
2013年第10期933-935,共3页
China Pharmacy
