摘要
目的:评价术中使用尖吻蝮蛇血凝酶对手术切口止血作用的有效性及安全性。方法:对行妇产科腹腔镜手术的40例患者术中分别采用尖吻蝮蛇血凝酶与氨甲环酸术中止血,并进行效果比较。尖吻蝮蛇血凝酶组20例,氨甲环酸氯化钠组20例。术中分别静脉给予尖吻蝮蛇血凝酶2 U、氨甲环酸氯化钠1 g。观察2组患者手术切口出血量、术中出血量、切口创面止血时间及术后3天血常规、凝血功能、肝肾功能变化情况。结果:2组患者的止血效果无显著性差异(P>0.05)。2组患者术后3天的血常规、凝血功能、肝肾功能检查结果与术前比较均无显著性差异。本组病例无不良事件发生。结论:尖吻蝮蛇血凝酶对手术伤口的止血作用与氨甲环酸氯化钠相似,均有较好的安全性。
Objective ： To evaluate the safety and the effect of hemocoagulase agkistrodon on hemostatic in the patients with laparoscope operation. Methods：40 patients with laparoscope operation were assigned to study group （hemoeoagulase agkistrodon 2 U, 20 cases） and control guoup （Tranexamic acid and sodium chloride 1 g,20 cases） ,then the two drugs were intravenously injected during operation. The hemostatic time, hemorrhagic volume, time and safety of surgery were observed. Results：The hemostasis effects between study group and control group were similar （ P 〉 0.05 ）. There were no significant difference in the blood routine, coagulative function, hemostatic function, hepatic and renal function between before and 3 days after the operation. No adverse event happened. Conclusion： Hemocoagulase agkistrodon is safe and effective on hemostasis in abdominal incision same as Transamin.
出处
《现代临床医学》
2013年第1期16-17,共2页
Journal of Modern Clinical Medicine
