摘要
目的探讨手术后危重患者血清心肌酶的变化与病情程度及预后的关系。方法将57例术后危重患者作为观察组,55例小型手术患者作为对照组,均在手术后3d内检测其血清心肌酶,并将结果进行比较。.结果观察组与对照组比较,观察组心肌酶显著升高,天冬氨酸氨基转移酶(AST)分别为(153.1±211.0)U/L与(54.7±39.0)U/L(t=3.404,P〈0.01);乳酸脱氢酶(LDH)分别为(381.0±216.1)U/L与(194.6±75.3)U/L(t=6.050,P〈0.01);肌酸激酶(CK)分别为(882.9±630.7)U/L与(130.1±71.8)U/L(t=8.796P〈0.01);肌酸激酶同工酶(CK-MB)分别为(314.3±164.2)U/L与(164.9±87.7)U/L(t=5.979,P〈0.01);Ot羟丁酸脱氢酶(d—HBDH)分别为(410.1±327.6)U/L与(27.8±36.3)U/L(t=8.605,P〈0.01)。观察组中病死率为24.6%(14/57),其中存活组心肌酶明显低于死亡组,AST分别为(81.3±40.5)U/L与(373.6±342.1)U/L(t=5.585,P〈0.01);LDH分别为(303.6±134.0)U/L与(618.6±250.1)U/L(t=6.064,P〈0.01);CK分别为(658.5±328.0)U/L与(1572.0±829.4)U/L(t=6.001,P〈0.01);CK.MB分别为(303.2±184.3)U/L与(738.6±445.6)U/L(t=5.242,P〈0.01);α-HBDH分别为(254.1±118.6)U/L与(499.3±147.6)U/L(t=6.320,P〈0.01))。结论心肌酶升高在手术后危重患者中普遍存在,心肌酶的变化程度与病情危重程度、手术的创伤程度有关。
Objective To explore the changes of the cardiac enzymes in the critical patients after operation and to analyze their relationship with the patient's condition level and the prognostic. Methods Fitty- seven critical patients after operation were enrolled to observation group, and 55 small operation patients acted as control group. Their cardiac enzymes in three days after operation were detected and compared. Results The cardiac enzymes of the observation group increased significantly when compared with the control group( aspartate aminotransferase (AST) ( 153.1 ±211.0) U/L vs ( 54.7 ±39. 0 ) U/L, t = 3.404, P 〈 O. Ol ) ; lactic acid dehydrogenase(LDH) (381.0 ±16. 1 ) U/L vs ( 194. 6 ±5.3) U/L,t = 6. 050,P 〈 0. 01 ) ; creatine kinase (CK) (882. 9 ±630. 7) U/L vs ( 130. 1 ± 71.8 ) U/L, t = 8.796, P 〈 O. 01 ) ; creatinine kinase, MB isoenzyme (CK-MB)(314.3 ±164.2) U/L vs (164.9 ±87.7) U/L, t = 5.979, P 〈 0.01) ; ot-hydroxybutyrate dehydrogenas(ot-HBDH) (410. 1 ±327. 6) U/L vs ( 27.8 ±36. 3 ) U/L, t = 8. 605, P 〈 0.01 ) ; The fatality ratio was 24. 6% ( 14/57 ) in the observation group. The cardiac enzymes of the survival group existed significant difference compared with the death group ( AST : ( 81.3 ±40. 5 ) U/L vs (373.6 ±342. 1 ) U/L, t = 5. 585, P 〈 0.01) ;LDH:(303.6±34.0) U/Lvs (618.6±50.1) U/L,t=6.064,P〈O. O1) ;CK:(658.5 ±28.0) U/Lvs (1572.0±29.4) U/L,t=6.001 P〈0.01) ;CK-MB:(303.2±84.3) U/Lvs (738.6 ±45.6) U/L,t = 5. 242 ,P 〈0. O1 ) ;α-HBDH: (254. 1 ±118.6) U/L vs (499. 3 ± 147.6) U/L,t =6. 320,P 〈0. 01 ). Conclusion Elevated myocardiac enzymes are common in the critical patients after operation. The change of the cardiac enzymes is related with the degree of disease and the wound.
出处
《中国综合临床》
2013年第3期285-288,共4页
Clinical Medicine of China
关键词
危重症
心肌酶谱
外科手术
Critical patients
Myocardial enzymes
Surgery