摘要
目的了解儿童肾小球疾病病理类型分布。方法回顾性分析1987年2月至2012年2月间收治的3090例肾小球疾病患儿的肾活检病理资料。结果在3090例患儿中,男女比为2.05:1;年龄(9.5±4.1)岁;原发性肾小球肾炎2 361例(76.4%),继发性肾小球肾炎687例(22.2%),遗传性肾病42例(1.4%)。原发性肾小球肾炎患儿病理分型依次为系膜增生44.7%,微小病变16.4%,毛细血管内增生14.7%,IgA肾病14.3%,轻微病变4.3%,局灶节段性肾小球硬化症3.4%,膜性肾病1.3%,膜增生性肾小球肾炎0.6%,新月体型肾炎0.3%。继发性肾小球肾炎患儿病理分型依次为紫癜性肾炎78.4%,乙肝相关性肾炎11.4%,狼疮性肾炎10.2%。结论儿童肾小球疾病以原发性肾小球疾病最为常见,男性多见,儿童原发肾小球肾炎最常见为系膜增生,儿童继发性肾小球肾炎最常见为紫癜性肾炎。
Objective To explore pathological features of glomerular diseases in children. Methods The pathological data of 3090 children with biopsy-proven glomerular diseases from February 1987 to February 2012 were analyzed retrospectively. Results The boy to girl ratio was 2.05：1 in 3090 children and the average age was （9.5±4.1） years. The clinical typing included primary glomerular disease 2 361 （76.4%）, secondary glomerular disease 687 （22.2%） and inherited kidney disease 42 （1.4%）. Among the children with primary glomerular disease, mesangial proliferative glomerulonephritis was the most frequent type （44.7%）, followed by minimal change glomerulopathy （16.4%）, endocapillary proliferation glomerulonephritis （14.7%）, IgA nephropathy （14.3%）, glomerular minor lesion （4.3%）, focal segmental glomerulosclerosis （3.4%）, membranous glomerulopathy （1.3%）, membranoproliferative glomerulonephritis （0.6%） and crescentic glomerulonephritis （0.3%）. Among the children with secondary glomerular disease, Henoeh-Schonlein purpura nephritis was the most frequent type （78.4%）, followed by hepatitis B virus-associated glomerulonephritis （11.4%） and lupus nephritis （10.2%）. Conclusions Primary glomerular disease was common in childhood glomerular diseases with a male predominance. The main pathological presentation in primary glomerular disease was mesangial proliferative glomerulonephritis. For secondary glomerular disease, Henoch-Sch6nlein purpura nephritis was the mostfrequent type.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2013年第2期157-158,161,共3页
Journal of Clinical Pediatrics
关键词
肾小球疾病
病理类型
流行病学
儿童
glomerular disease
pathological classification
epidemiology
child
