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Th17细胞与免疫性血小板减少症 被引量：6

The Th17 Cells with Immune Thrombocytopenic Purpura
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摘要 免疫性血小板减少症（immunethmml）0cytopenicpurpura，ITP）是一种获得性自身免疫性出血性疾病，以免疫介导的血小板减少为特征。已知ITP主要机制是自身抗血小板抗体的产生，与血小板结合，吸附于血小板表面后作用于血小板抗原，加速血小板被循环中的单核巨噬细胞系统清除，导致血小板减少。随着近年来深人的研究，发现除体液免疫外，细胞免疫在ITP的发病机制中的作用不容忽视。
作者 李鑫 丁凯阳
机构地区 安徽医科大学附属省立医院血液内科
出处 《血栓与止血学》 2013年第1期37-40,共4页 Chinese Journal of Thrombosis and Hemostasis
关键词 免疫性血小板减少症 TH17细胞 白介素17
分类号 R558 [医药卫生—血液循环系统疾病]
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参考文献20

  • 1SEMPLE JW,PROVAN D,GARVEY MB,el al. Recent progress in understanding the pathogenesis of immune thrombocytopenia[J].Current Opinion in Hematology,2012.590-595.
  • 2YANG J,YANG X,ZOU H. Recovery of the immune balance between Th17 and regulatory T cell as a treatment for systemic lupus etythematosus[J].Rheumatology(Oxford),2011.1366-1372.
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二级参考文献32

  • 1凌云,曹祥山,余自强,罗光华,白霞,苏健,戴兰,阮长耿.CD4^＋CD25^＋调节性T细胞在特发性血小板减少性紫癜患者中的变化[J].中华血液学杂志,2007,28(3):184-188. 被引量：17
  • 2Kuwana M,Kawakami Y,Ikeda Y.Suppr ession of autoreactive T2 cell response to glycoprotein Ⅱ b/Ⅲ a by blockade of CD40/CD154 interaction:implications for treatment of immune thrombocytopenic purpura.Blood,2003,101:621-623.
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  • 5Ma DX,Zhu XJ,Zhao P,et al.Profile of Th17 cytokines (IL-17,TGF-β,IL-6) and Th1 cytokine (IFN-r) in patients with immune thrombocytopenic purpura.Ann Hematol,2008,87:899-901.
  • 6Zhou RF,Yang JQ,Chang DY,et al.Profiles of Th1,Th2,Th17 and Treg Cells in Patients with Chronic Idiopathic Thrombocytopenic Purpura.Blood (ASH Annual Meeting Abstracts),2008,112:4907.
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二级引证文献31

血栓与止血学
2013年 第1期

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