摘要
目的研究急性白血病(AL)患者治疗过程中并发感染与DIC发生情况,探讨联合监测CRP和D-D对AL并发DIC的早期预测价值。方法选取该院AL患者67例,其中并发感染51例,并发DIC15例,健康对照21例,分别检测静脉血CRP、D-D含量,对检测结果进行统计学分析。结果以AL患者是否并发感染及DIC分组:单纯AL患者CRP和D-D分别为16.7±6.1mg/L、0.54±0.21μg/mL,AL并发感染患者CRP和D-D分别为95.6±34.3mg/L、0.72±0.35μg/mL,AL并发感染患者CRP和D-D分别为116.4±42.5mg/L、4.3±1.7μg/mL,经统计学检验均与健康对照存在显著差异(P<0.05),AL并发DIC患者D-D较非DIC的AL患者高(P<0.05)。以不同CRP含量分组:15例发生DIC患者中有9例CRP≥100mg/L,AL患者不同CRP水平之间DIC发生率呈明显差异。结论 AL合并感染患者易并发DIC,CRP和D-D联合监测对AL患者预测DIC发生有重要临床价值。
Objective To study the relation of infection and disseminated intravascular coagulation（DlC） in acute leukemia（AL） patients,and to know the early predictive value of combined monitoring of C reactive protein（CRP） and D-dimer（D-D） in DIC in-duced by AL. Methods 67 cases of AL patients and 21 cases of health people undergoing physical examination were entrolled. The concentrations of CRP and D-D were simultaneous measured,and the results were analyzed by statistical methods. Results 67 cases of AL patients were divided into 3 groups according to whether complicated infection and DIC. The concentrations of CRP and D-D in uncomplicated AL group were（16.7±6.1）mg/L and（0.54±0.21） μg/mL. The concentrations of CRP and D-D in AL combined with infection group were（95.6±34.3）mg/L and（0.72±0.35）vg/mL. The concentrations of CRP and D-D in AL combined with DIC group were（ 116.4 ± 42.5）mg/L and（4.3 ± 1.7）μg/mL. The statistical results suggested that the levels of CRP and D-D in AL patients are significantly different from those of health people（P〈0.05）. The level of D-D in AL combined with DIC group was significantly higher than that of other AL patients（P〈0.05）. 67 AL patients were divided into different groups according to the CRP concentrations. Among 15 cases of AL pateints comlicated DIC,there were 9 cases having CRP concentrations higher than 100 mg/L. The incidence of DIC had significant devialtion in different levels of CRP. Conclusion Combined detection of CRP and D-D has important clinical value to predict DIC in AL.
出处
《国际检验医学杂志》
CAS
2013年第4期430-431,434,共3页
International Journal of Laboratory Medicine
