摘要
目的探讨十二指肠神经内分泌癌（duodenal neuroendocrine carcinoma,DNEC）的临床病理学特征与外科治疗效果。方法回顾性分析2009-2012年于我院治疗的8例DNEC的临床病理学特征与外科治疗效果并复习文献。结果 8例DNEC中,男性5例,女性3例;发病年龄28~80岁,平均年龄53岁;主要临床表现为皮肤巩膜黄染5例,上腹及腰背部疼痛5例,黑便1例,1例无症状;肿瘤位于十二指肠降段4例,乳头3例,水平段1例;腹部影像呈多样性,CT可呈十二指肠乳头或相应部位肿物。4例行胰十二指肠切除术,2例行内窥镜逆行胆总管造影并胆管支架置入术（ERCP）,2例行胃肠吻合并超声引导经皮经肝胆道造影置管引流术（PTCD）;术后随访3~40个月,4例行根治性切除患者均长期存活,4例行姑息性治疗患者均已死亡。结论十二指肠神经内分泌癌呈浸润性生长,应积极手术治疗以改善患者预后。
Objective To study the clinicopathological features of duodenal neuroendocrine carcinoma（DNEC） and its surgical treatment outcome.Methods Clinical data about 8 DNEC patients and its surgical treatment outcome were retrospectively analyzed with its related literature reviewed.Results Of the 8 DNEC patients,5 were males and 3 were females.They developed DNEC at the age of 53 years（mean 28-80 years）.DNEC was mainly manifested as jaundice in 5 cases,as abdominal pain in 5 cases,and as melena in 1 case.No symptom was observed in 1 case.The tumor was located at descendant duodenum in 4 cases,at duodenal papilla in 3 cases,at horizontal duodenum in 1 case.CT scan showed DNEC at duodenal papilla or its corresponding sites.Of the 8 patients,4 underwent pancreaticoduodenectomy,2 underwent ERCP and bile duct stenting,2 underwent gastroenterostomy and PTCD.The patients were followed up for 3-40 months after operation.The 4 patients who underwent radical excision were still alive while the other 4 patients who underwent palliative therapy died.Conclusion DNEC is an infiltrative growth tumor.Surgical resection can improve the prognosis of its patients.
出处
《解放军医学院学报》
CAS
2013年第2期140-141,147,共3页
Academic Journal of Chinese PLA Medical School
关键词
十二指肠
神经内分泌癌
诊断
治疗
duodenum
neuroendocrine carcinoma
diagnosis
treatment
