摘要
目的制备槲皮素微乳凝胶,并对其性能及透皮效果进行研究。方法根据已优化的槲皮素微乳的处方并将微乳制成凝胶,采用Franz扩散池对槲皮素微乳凝胶的体外透皮情况进行考察。结果从体外透皮实验可见,与槲皮素混悬液凝胶比较,槲皮素微乳凝胶的体外透过量明显增加(P<0.05)。结论槲皮素微乳凝胶的制备工艺可行,且能促进槲皮素的透皮转运量。
Objective To prepare the microemulsion-based gel of quercetin,and to study its quality evaluation and its percutanous penetration properties in vitro.Methods The microemulsion-based gel was prepared according to the optimized prescription of quercetin microemulsion.The in vitro percutanous penetration of Quercetin microemulsion-based gel was studied by using Franz diffusion cell.Results Compared with quercetin from suspension gel,in vitro penetration amount of quercetin microemulsion gel increased obviously（P0.05）.Conclusion Preparation technology of the microemulsion-based gel of quercetin is workable,which can promote the transdermal transport of quercetin.
出处
《安徽医药》
CAS
2012年第8期1076-1078,共3页
Anhui Medical and Pharmaceutical Journal
基金
2009年浙江省大学生创新科技(新苗人才计划)项目资助(No 200901)
关键词
槲皮素
微乳
凝胶
体外透皮
quercetin
microemulsion
gel
percutanous penetration in vitro
