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电针百会、风府穴对学习记忆障碍大鼠Bcl-2/Bax基因表达的影响 被引量：10

Effect on Bcl-2/Bax Protein Gene Expression in Cognitive Dysfunction Rats by Acupuncturing Baihui and Fengfu Points
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摘要 目的:研究电针百会、风府穴对学习记忆障碍大鼠脑组织神经细胞凋亡及Bcl-2、Bax基因表达的影响,探讨其改善学习记忆障碍的机制以及对脑组织神经元的保护作用。方法:随机将48只雄性Wistar大鼠分为假手术组、模型组、电针组和西药组。采用D-半乳糖腹腔注射合并脑内双侧Meynert鹅膏草氨酸注射的方法制做复合型学习障碍模型,运用电针百会、风府穴的方法进行治疗。结果与结论:电针百会、风府穴能够通过提高Bcl-2基因表达的途径抑制细胞凋亡,保护脑内神经元,进而改善大鼠的学习记忆能力。 Objective：To study the effect on apoptosis and Bcl-2/Bax protein gene expression in cognitive dysfunction rats with the method of acupuncturing Baihui（GV20） and Fengfu（GV16） points.Method：48 healthy Wistar rats were randomly divided into control group,model group,medication group and acupuncture group.The animal models were established by poritoneal injection of D-galactose for six weeks combined with ibotenic acid injection into bilateral nucleus basalis of Meynert.Treated with acupuncture Baihui（GV20） and Fengfu（GV16） points.Conclusion：Acupuncturing Baihui（GV20） and Fengfu（GV16） points can cause the inhibition of apoptosis and protect the hippocampal neurons by promoting expression of Bcl-2 gene,and then improve the rats＇ability of learning and memory.
作者 张迪 邓俏 孙阳
机构地区 黑龙江中医药大学附属第一医院 哈尔滨医科大学附属第一医院
出处 《中医药信息》 2013年第1期73-75,共3页 Information on Traditional Chinese Medicine
基金 黑龙江省科技厅青年基金计划项目(QC08C75)
关键词 老年性痴呆 电针 学习记忆障碍 BCL-2 BAX Dementia Electroacupuncture Barrier of learning and memory Bcl-2 Bax
分类号 R245 [医药卫生—针灸推拿学]
  • 相关文献

参考文献10

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二级参考文献17

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共引文献17

同被引文献124

引证文献10

二级引证文献213

中医药信息
2013年 第1期

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