摘要
目的比较度洛西汀与西酞普兰治疗伴疼痛症状的抑郁症的疗效及安全性。方法60例伴疼痛症状的抑郁症患者随机分为度洛西汀组(n=30)和西酞普兰组(n=30),治疗8周。用汉密顿抑郁量表(HAMD)、汉密顿焦虑量表(HAMA)和副反应量表(TESS)评定疗效及不良反应。结果治疗后两组HAMD评分及HAMA评分均较治疗前显著下降(P均<0.01),度洛西汀组HAMD总分及全身症状分较西酞普兰组下降显著(P<0.05或P<0.01),且度洛西汀组起效较快;两组不良反应差异无统计学意义(P>0.05)。结论度洛西汀与西酞普兰治疗伴疼痛症状的抑郁症均有效,但以度洛西汀起效快,疗效更好。
Objective To compare efficacy and safety of duloxetine and citalopram in the treatment of de- pression with pain symptoms. Methods 60 patients were randomly divided into duloxetine group （n = 30） and citalopram group （ n = 30） for 8 weeks treatment. Hamilton rating scale for depression （ HAMD）, Hamilton rating scale for anxiety （HAMA） and treatment emergent symtom scale （TESS） were used to evaluate the efficacy and side effects respectively. Results The total sores of HAMD and the total sores of HAMA in both group after treat- ment were all significantly lower than those in baseline （P 〈0. 01 ）, the total and somatic symptom sores of HAMD in duloxetine group was significantly lower than citalopram group （P 〈0. 05 or P 〈0. 01 ）. There were no signifi- cant difference in side effect between these two groups （P 〉 0. 05）. Conclusion Both duloxetine and citalopram are effective in the treatment of depression with pain symptoms, duloxetine is earlier response and more effective.
出处
《国际精神病学杂志》
2013年第1期4-6,共3页
Journal Of International Psychiatry
