摘要
目的:分析探讨实时组织弹性成像(real-time tissue elastography,RTE)技术对肝纤维化的诊断效能。方法:应用RTE技术对41例慢性乙肝患者的肝纤维化指数(liver fibrosis index,LF index)进行定量检测以评价肝脏纤维化程度,同时进行生化检测及肝活检,以病理结果为诊断金标准,进行对照分析。结果:肝纤维化分期各组的LF index、天冬氨酸氨基转移酶/血小板比值指数(AST-to-platelet ratio index,APRI)、FIB-4(fibrosis index based on the 4 factor)指数比较,差异均有统计学意义(P<0.05),且LF index、APRI、FIB-4指数与纤维化分期呈正相关(P均<0.001)。LF index与APRI、FIB-4指数间呈正相关(P<0.01)。肝纤维化S4期作为早期肝硬化的诊断标准时,LF index、APRI、FIB-4指数的受试者工作特征曲线下面积分别为0.934(P<0.001)、0.851(P<0.001)、0.899(P<0.001)。结论:RTE技术对肝纤维化程度具有一定的诊断效能,具有潜在的临床实用价值。
Objective：The purpose of this study is to analyze and discuss the efficiency of real-time tissue elastography（RTE） in diagnosis of liver fibrosis.Methods：RTE was performed on 41 patients with chronic hepatitis B to measure the stage of liver fibrosis, from which a quantitative parameter-liver fibrosis index（LF index） was obtained.Simultaneously,biochemical test and liver biopsy were performed in all patients.We compared the results among different stages of S1,S2,S3 and S4 liver fibrosis reported by biopsy considered as the gold standard for the assessment of liver fibrosis.Results：Significantly different were found in LF index,APRI and FIB-4 of liver fibrosis groups（P﹤0.05）.LF index,APRI and FIB-4 increased as the stage of liver fibrosis（P 0.001）.LF index correlated positively with APRI,FIB-4,respectively（P﹤0.01）.Taking S4 as the diagnosis standard of early liver cirrhosis,the area under the curve of ROC for LF index,APRI and FIB-4 was 0.934（P 0.001）,0.851（P 0.001）,0.899（P 0.001）,respectively.Conclusion：RTE with potential practical value in the clinical has certain diagnostic efficiency in evaluating the stage of liver fibrosis.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2013年第1期131-134,共4页
Journal of Nanjing Medical University(Natural Sciences)
基金
卫生部科研基金(LW201001)
关键词
超声检查
弹性成像
肝纤维化
ultrasonography
elastography
liver fibrosis
