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心肌血流储备分数在临界病变的非ST段抬高急性冠脉综合征患者中的应用 被引量：3

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摘要 目的:探讨心肌血流储备分数(fractional flow reserve,FFR)在稳定临界病变的非ST段抬高急性冠脉综合征(non-ST-segment elevation acute coronary syndrome,NSTEACS)患者中的应用。方法:冠状动脉造影(coronary angiography,CAG)明确冠状动脉病变直径狭窄40%～70%的NSTEACS、FFR测定值≥0.75不需行经皮冠脉介入治疗(percutaneous transluminal coronaryintervention,PCI)的患者32例,排除CAG显示的不稳定斑块,平均年龄(68.6±11.4)岁。主要终点事件为1年内的心源性死亡、非致死性心肌梗死、靶病变血运重建及因心脏原因再入院。结果:32例患者共36处病变,14例(43.8%)为非ST段抬高心肌梗死,CAG显示的平均直径狭窄率为(41.6±7.8)%,平均FFR值为0.86±0.08,术中无并发症发生。1年随访率100%;未见死亡和致死性心肌梗死发生,1例(3.1%)靶血管血运重建和2例(6.3%)因心脏原因再入院,90.6%患者未见任一主要终点事件发生。结论:对排除不稳定斑块且CAG显示冠状动脉临界病变的NSTEACS患者,FFR测定有助于避免不必要的血运重建。
作者 汤成春 李拥军 罗丹 鞠成伟 马根山 陈忠 章晓国 鞠翔 谢学玲
机构地区 东南大学附属中大医院心内科
出处 《南京医科大学学报（自然科学版）》 CAS CSCD 北大核心 2013年第1期83-85,共3页 Journal of Nanjing Medical University(Natural Sciences)
关键词 心肌血流储备分数 冠脉造影 急性冠脉综合征 临界病变 血运重建
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献6

  • 1汤成春,马根山,冯毅,陈忠,鞠成伟,章晓国,王润民,陈琴芬,鞠翔,谢学玲.心肌血流储备分数在冠心病介入治疗中的应用[J].江苏医药,2011,37(8):918-920. 被引量：16
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二级参考文献8

  • 1Applegate RJ. Fractional flow reserve-guided stent therapy for multivessel disease: taking a closer look[J]. J Am Coll Cardiol, 2010,55 (25) : 2822-2824.
  • 2Tonino PA, Fearon WF, De Bruyne B, et al. Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation[J]. J Am Coll Cardiol, 2010, 55 (25): 2816-2821.
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  • 6Tonino PA, De Bruyne B, Piils NH, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention[J].N Engl J Med,2009, 360(3) : 213-224.
  • 7Pijls NH, van Son JA, Kirkeeide RL, et al. Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity before and after percutaneous transluminal coronary angioplasty[J]. Circulation, 1993, 87 (4) : 1354-1367.
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共引文献15

同被引文献18

  • 1Nico HJ,Pi]ls NH,Jan-Willem EM, et al. Functional measure- ment of coronary stenosis. J Am Coll Cardiol,2012,59;1045- 1057.
  • 2Lee BK, Choi HH, Hong KS, et al. Efficacy of fractional flow reserve measurements at side branch vessels treated with the crush stenting technique in true coronary bifurcation lesions. Clin Cardiol, 2010,33: 490-494.
  • 3Tonino PA, De Bruyne B, Pijls NH, et al. Fractional flow re serve versus angiography for guiding percutaneous coronary in tervention. N Engl J Med,2009,360:213-224.
  • 4Applegate RJ. Fractional flow reserve guided stent therapy for multivessel disease: taking a closer look. J Am Coll Cardiol, 2010,55 : 2822-2824.
  • 5Lee BK, Choi HH, Hong KS, et al. Efficacy of fractional flow reserve measurements at side branch vessels treated with the crush stenting technique in true coronary bifurcation lesions J ]. Clin Cardiol, 2010,33 ( 8 ) :490-494.
  • 6Pijls NH, van Sehaardenburgh P, Manoharan G, et al. Percutane- ous coronary intervention of functionally nonsignificant stenosis: 5- year follow-up of the DEFER Study[ J]. J Am Coll Cardiol,2007, 49(21 ) :2105-2111.
  • 7Courtis J, Rodos-Cabau J, Larose E, et al. Usefulness of coronary fractional flow reserve measurements in guiding clinical decisions in intermediate or equivocal left main coronary stenoses [ J ]. Am J Cardio1,2009,103 ( 7 ) :943-949.
  • 8Applegate RJ. Fractional flow reserve guided stent therapy for mul- tivessel disease : taking a closer look [ J]. J Am Coil Cardiol,2010, 55 ( 25 ) :2822-2824.
  • 9Tonino PA, De Bruyne B, Pijls NH, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention [J]. N Engl J Meal,2009, 360(3) :213-224.
  • 10翟红霞,夏云峰,刘润梅,李良,殷亚昕,张津津.老年冠心病患者冠状动脉病变特点[J].中华老年心脑血管病杂志,2008,10(5):344-346. 被引量：12

引证文献3

二级引证文献27

南京医科大学学报（自然科学版）
2013年 第1期

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