摘要
脑微血管内皮细胞(brain microvascular endothelialcells,BMECs)是构成血脑屏障的主要成分,与脑水肿、脑缺血以及脑肿瘤等脑血管疾病的发生、发展密切相关。BMECs原代培养模型已被广泛应用于血脑屏障、脑血管疾病的病理、生理及分子生物学研究。该文对近年来国内外有关BMECs原代培养的方法进行综述,为脑血管疾病的研究提供基础。
The brain microvascular endothelial cells（BMECs） are the main components of the blood-brain barrier,which are closely related to the occurrence and development of cerebral edema,cerebral ischemia,brain tumors and other cerebrovascular diseases.The primary culture model of BMECs has been widely used to research pathophysiology and molecular biology in blood-brain barrier and cerebrovascular disease.The article summarizes the methods of BMECs in primary culture at home and abroad in recent years,thus it provides a foundation for the study of cerebrovascular diseases.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2013年第2期294-296,共3页
Chinese Pharmacological Bulletin
基金
国家自然科学基金面上项目(No 30973979)
安徽省优秀青年科技基金(No 10040606Y17)
康缘中医药创新基金(No zlgc200944)
关键词
脑微血管内皮细胞
细胞原代培养
分离
纯化
鉴定
brain microvascular endothelial cells
cells in primary culture
separation
purification
identification
