摘要
随着全基因组测序技术的发展和测序成本的下降,以及全基因组测序技术与DNA甲基化和组蛋白乙酰化等表观遗传学分析手段的结合,对大量样本进行全面系统的分析已经成为现实,人类已具备了重新认识肿瘤发生发展的能力。从以往的不同个体之间的全基因组序列的比对,到最近大量自身不同组织的横向比对,自身基因组的纵向比对,新思路层出不穷,个体化诊治肿瘤已显露出光明的前景。
With the development of sequencing technology,the cost of whole-genome sequencing was significantly declined. Meanwhile, with the application of combined whole-genome sequencing with epigenetic analysis on methylation and histone acetylation,the comprehensive and systematic analysis of numerous samples became a reality and we are able to re-understand the genesis and development of cancer. New ideas are emerging in comparative genomics research methods, from comparison of genomes among different individuals to horizontal self-comparison of different tissues and vertical self-comparison of genomes recently. Individualized diagnosis and treatment of cancer has shown a bright future.
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2013年第1期103-108,共6页
Journal of Zhejiang University(Medical Sciences)
基金
国家自然科学基金资助项目(No.81273578)
台州市科技计划资助项目(No.091KY04)
关键词
基因组
碱基序列
遗传
序列同源性
核酸
序列比对
肿瘤
Genome
Base sequence/genetics
Sequence homology, nucleic acid
Sequence alignment
Neoplasms
