摘要
背景术后慢性疼痛的发生率远远高于预期，严重影响患者术后的生活质量，由于缺乏对其机制的认识和特效的治疗，术后慢性疼痛的问题日益突出。目的探讨术后慢性疼痛发生的特点、危险因素及其可能的发病机制。内容术前术后的多种危险因素均影响术后慢性疼痛的发生，其产生并非某一机制单独作用的过程，而是神经损伤、神经重塑、慢性炎症各等种因素之间相互作用的综合结果。趋向麻醉医生应提高对于术后慢性疼痛的认识，在寻求其发病机制的同时，探究多种方式的超前镇痛等可行的临床治疗方案。
Background The incidence of postoperative chronic pain is much higher than expected, seriously affecting the quality of patients＇ life. Chronic pain after surgery is becoming increasingly prominent due to the lack of mechanism knowledge and effective treatments. Objective This review is to investigate the characteristics, risk factors and possible pathogenesis of postoperative chronic pain. Content Postoperative chronic pain is caused by multiple risk factors, which consist of preoperative factors, operative factors and postoperative factors. The development of chronic pain is a comprehensive process with various mechanisms, including nerve damage, nerve remodeling, and chronic inflammation. Trend Anesthesiologist should pay more attention to postoperative chronic pain, and try to seek its pathogenesis and explore its possible clinical treatments, such as preemptive analgesia.
出处
《国际麻醉学与复苏杂志》
CAS
2013年第2期163-166,共4页
International Journal of Anesthesiology and Resuscitation
关键词
慢性疼痛
危险因素
神经损伤
神经重塑
慢性炎症
Chronic pain
Risk factors
Nerve injury
Nerve remodeling
Chronic inflammation
